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Differential modulation of cancer-related molecular networks in human and rat urinary bladder cells exposed to triralent arsenicals

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Citation:

Bailey, K. A., K. WALLACE, S. Y. THAI, D. WOLF, S. W. EDWARDS, AND R. C. Fry. Differential modulation of cancer-related molecular networks in human and rat urinary bladder cells exposed to triralent arsenicals. Presented at Society of Toxicology, Washington, DC, March 06 - 10, 2011.

Impact/Purpose:

Distinct from the other groups, MMAIII exposure in UROtsa cells generated changes in several molecular networks that are consistent with pathways suspected to play key roles in human UB carcinogenesis, suggesting that common factors may drive UB carcinogenesis in humans and that they may be distinct from those in rats.

Description:

We used a transcriptomics approach to examine the altered arsenicals to investigate the MOA of As-driven UB carcinogenesis.

URLs/Downloads:

EDWARDS SOT.PDF  (PDF, NA pp,  80  KB,  about PDF)

Record Details:

Record Type:DOCUMENT( PRESENTATION/ POSTER)
Product Published Date:03/10/2011
Record Last Revised:12/05/2012
OMB Category:Other
Record ID: 230527