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Records 1 to
25
of 92 records from author Patricia Kosian
2022
Haselman, Jonathan, J. Olker, P. Kosian, J. Korte, J. Denny, J. Tietge, M. Hornung, AND S. Degitz. Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus Laevis Using Iopanoic Acid. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 187(1):139-149, (2022). https://doi.org/10.1093/toxsci/kfac014
2021
Ford, J., C. Riutta, K. OShaughnessy, P. Kosian, I. Hassan, AND Mary E. Gilbert. Reducing Uncertainties in Quantitative AOPs by Analysis of Thyroid Hormone in the Neonatal Rat Brain. Society of Toxicology 2021 Virtual Annual meeting, Virtual, NC, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.14473662
2020
Haselman, Jonathan, J. Olker, P. Kosian, J. Korte, J. Swintek, J. Denny, J. Nichols, J. Tietge, M. Hornung, AND S. Degitz. Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine as a surrogate metric of metamorphic success in model amphibian Xenopus laevis. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 175(2):236-250, (2020). https://doi.org/10.1093/toxsci/kfaa036
2019
Serrano, J., Rick Kolanczyk, M. Tapper, T. Lahren, N. Dongari, D. Hammermeister, Pat Kosian, P. Schmieder, B. Sheedy, K. Challis, AND A. Kubatova. Characterization and analysis of estrogenic cyclic phenone metabolites produced in vitro by rainbow trout liver slices using GC-MS, LC-MS and LC-TOF-MS. Journal of Chromatography B. Elsevier Science Ltd, New York, NY, 1126-1127:1-12, (2019). https://doi.org/10.1016/j.jchromb.2019.121717
Mayasich, S., J. Denny, J. Korte, P. Kosian, J. Olker, P. Degoey, J. O'Flanagan, S. Degitz, AND M. Hornung. Characterization of Xenopus laevis iodothyronine deiodinase (DIO3) enzyme and chemical inhibition comparison with human DIO3. North American Society for Comparative Endocrinology, Gainsville, FL, May 24 - 28, 2019.
Serrano, J., R. Kolanczyk, M. Tapper, T. Lahren, B. Sheedy, P. Kosian, AND A. Kubatova. Mass spectrometric identification and estrogenic potential of cyclic phenone metabolites formed in in vitro assays with fish liver slices. American Society for Mass Spectrometry, Atlanta, GA, June 02 - 06, 2019.
Serrano, J., M. Tapper, Rick Kolanczyk, B. Sheedy, T. Lahren, D. Hammermeister, J. Denny, M. Hornung, A. Kubatova, P. Kosian, J. Voelker, AND P. Schmieder. Metabolism of cyclic phenones in rainbow trout in vitro assays. XENOBIOTICA. Taylor & Francis, Inc., Philadelphia, PA, 50(2):115-131, (2019). https://doi.org/10.1080/00498254.2019.1596331
Riutta, C., I. Hassan, J. Ford, P. Kosian, Katherine OShaughnessy, S. Degitz, AND M. Gilbert. Thyroid Hormone Measurements in Rat Brain by Mass Spectrometry. Developmental Neurotoxicology Society (DNTS), San Diego, CA, June 23 - 26, 2019.
2018
Gilbert, M., R. Ford, S. Thomas, S. Spring, W. Oshiro, Pat Kosian, J. Ford, AND S. Degitz. Cortical Brain Malformation and Learning Impairments Induced by Developmental Thyroid Hormone Insufficiency: A Cross-Fostering Study. SOT, Baltimore, MD, March 12 - 16, 2017.
OShaughnessy, K., Pat Kosian, J. Ford, W. Oshiro, S. Degitz, AND M. Gilbert. Developmental Thyroid Hormone Insufficiency Induces Cortical Brain Malformation and Learning Impairments: A Cross-Fostering Study. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1):101-115, (2018).
Haselman, J., Pat Kosian, Joe Korte, A. Olmstead, AND S. Degitz. Effects of multiple life stage exposure to the fungicide prochloraz in Xenopus laevis: Manifestations of antiandrogenic and other modes of toxicity. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 199:240-251, (2018).
Olker, J., J. Haselman, Pat Kosian, K. Donnay, Joe Korte, C. Blanksma, M. Hornung, AND S. Degitz. Evaluating iodide recycling inhibition as a novel molecular initiating event for thyroid axis disruption in amphibians. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 166(2):318-331, (2018). https://doi.org/10.1093/toxsci/kfy203
Haselman, J., Pat Kosian, K. Donnay, M. Hornung, Joe Korte, J. Denny, J. Olker, R. Schulte, C. Knutsen, AND S. Degitz. In vivo deiodinase inhibition by iopanoic acid causes thyroid axis disruption and dysmorphogenesis in model amphibian species Xenopus laevis. Society of Toxicology Meeting, San Antonio, TX, March 11 - 15, 2018.
OShaughnessy, K., C. Wood, R. Ford, Pat Kosian, M. Hotchkiss, S. Degitz, AND M. Gilbert. Thyroid hormone disruption in the fetal and neonatal rat: Predictive hormone measures and bioindicators of hormone action in the developing cortex- ToxSci. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, , 163-179, (2018). https://doi.org/10.1093/toxsci/kfy190
OShaughnessy, K., S. Thomas, Pat Kosian, S. Degitz, AND M. Gilbert. Transient Maternal Hypothyroidism Alters Neural Progenitor Expression Resulting in Abnormal Brain Development. SOT, Baltimore, MD, March 12 - 16, 2017.
Haselman, J., J. Christensen, J. Olker, Pat Kosian, K. Donnay, P. DeGoey, M. Hornung, AND S. Degitz. Use of CRISPR/Cas9-mediated gene disruption in Xenopus tropicalis to evaluate thyroid-related targets of toxicological concern. SETAC North America, Sacramento, CA, November 04 - 08, 2018.
2017
Olker, J., K. Donnay, J. Haselman, Pat Kosian, Joe Korte, M. Hornung, AND S. Degitz. A tiered approach to evaluate an iodine recycling inhibition adverse outcome pathway (AOP) in amphibians. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.
Kosian, Pat, Joe Korte, K. Donnay, R. Ford, J. Haselman, M. Hornung, J. Ford, M. Gilbert, AND S. Degitz. Analysis of thyroid hormones in biological samples using stable isotope dilution liquid chromatography-tandem mass spectrometry. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.
Haselman, J., J. Nichols, M. Hornung, Pat Kosian, J. Olker, Joe Korte, AND S. Degitz. Computational modeling of the amphibian thyroid axis supported by targeted in vivo testing to advance quantitative adverse outcome pathway development. National Society of Toxicology Annual Meeting, Baltimore, MD, March 12 - 16, 2017.
Olker, J., J. Haselman, Pat Kosian, Joe Korte, M. Hornung, AND S. Degitz. Evaluating iodide recycling inhibition as a novel molecular initiating event for thyroid axis disruption. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.
Cavallin, J., G. Ankley, B. Blackwell, C. Blanksma, K. Fay, K. Jensen, M. Kahl, D. Knapen, Pat Kosian, S. Poole, E. Randolph, A. Schroeder, L. Vergauwen, AND Dan Villeneuve. Impaired swim bladder inflation in early-life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid (article). ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 36(11):2942-2952, (2017).
Cavallin, J., G. Ankley, B. Blackwell, C. Blanksma, K. Fay, K. Jensen, M. Kahl, D. Knapen, Pat Kosian, S. Poole, E. Randolph, A. Schroeder, L. Vergauwen, AND Dan Villeneuve. Impaired swim bladder inflation in early-life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid (presentation). SETAC Midwest Chapter, Minneapolis, MN, March 20 - 22, 2017.
Hassan, I., H. El-Masri, Pat Kosian, J. Ford, S. Degitz, AND M. Gilbert. Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 160(1):57-73, (2017).
Hassan, I., H. El-Masri, Pat Kosian, J. Ford, R. Ford, M. Jasper, S. Degitz, AND M. Gilbert. Quantitative Adverse Outcome Pathway for Neurodevelopmental Effects of Thyroid Peroxidase-Induced Thyroid Hormone Synthesis Inhibition. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.
Gilbert, M., S. Spring, J. Ford, R. Ford, C. Wood, S. Thomas, K. OShaughnessy, M. Hotchkiss, Pat Kosian, AND S. Degitz. Thyroid Hormone Insufficiency in the Pregnant Rat Induces Cortical Heterotopia in Offspring: PTU vs Perchlorate. Developmental Neurotoxicology Society (DNTS), Denver, Colorado, June 24 - 29, 2017.