Science Inventory

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Slikker, W., L. Wu, J. Xu, AND T. Shafer. 7.11 - In pursuit of precision medicine for brain injury and neurotoxicity and improved protection of human health. Edition First, Kenneth S. Ramos (ed.), Comprehensive Precision Medicine. ELSEVIER, AMSTERDAM, Holland, 2:495-510, (2024). https://doi.org/10.1016/B978-0-12-824010-6.00048-4

Judson, R., D. Smith, M. Devito, J. Wambaugh, B. Wetmore, K. Friedman, G. Patlewicz, R. Thomas, R. Sayre, J. Olker, S. Degitz, S. Padilla, J. Harrill, T. Shafer, AND K. Carstens. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS). Society of Toxicology (SOT) 63rd Annual Meeting and ToxExpo, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25451677

Judson, R., D. Smith, M. Devito, J. Wambaugh, B. Wetmore, K. Friedman, G. Patlewicz, R. Thomas, R. Sayre, J. Olker, S. Degitz, S. Padilla, J. Harrill, T. Shafer, AND K. Carstens. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS) (Toxics). Toxics. MDPI, Basel, Switzerland, 12(4):271, (2024). https://doi.org/10.3390/toxics12040271

Fitzpatrick, H., K. Wallace, T. Freudenrich, M. Mayil Vahanan, K. Carstens, AND T. Shafer. Characterization of signaling pathways in in vitro developmental neurotoxicity battery (TSfN). Presented at 9th Annual Triangle Society for Neuroscience (TSfN), Durham, NC, April 26, 2024.

Carstens, K., E. Gronskaya, D. Jaeckel, T. Shafer, M. Zurich, AND D. Pamies. Comparison of a high-density microelectrode array (MEA) assay for neurotoxicity screening using a 3D human iPSC-derived brain organoid model versus a 2D rat cortical cell model. International Conference on Developmental Neurotoxicity Testing (DNT5), Konstanz, GERMANY, April 07 - 10, 2024. https://doi.org/10.23645/epacomptox.25742760

Rice, O., Q. Krantz, E. Puckett, P. Evansky, K. Wallace, T. Freudenrich, M. Higuchi, AND T. Shafer. Development Of A Novel in Vitro Method to Study Effects of Volatile Compounds on Neural Activity. Society of Toxicology (SOT) 63rd Annual Meeting and ToxExpo, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25407025

Conley, J., S. Boyd, E. Hunter, AND T. Shafer. Development of a Functional Assay using Human Brain Organoids to Study Developmental Neurotoxicity. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25488151

Rice, O., Q. Krantz, E. Puckett, P. Evansky, K. Wallace, T. Freudenrich, M. Higuchi, AND T. Shafer. Development of a Novel in Vitro Method to Study Effects of Volatile Compounds on Neural Activity (TSfN). 9th Annual Triangle Society for Neuroscience (TSfN), Durrham, NC, April 26, 2024.

Mayil Vahanan, M., T. Shafer, K. Friedman, AND K. Carstens. Evaluating two analysis methods for the microelectrode array network formation assay. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25565175

Mayil Vahanan, M., T. Shafer, AND K. Carstens. Evaluating two analysis methods for the microelectrode array network formation assay (TSfN). 9th Annual Triangle Society for Neuroscience (TSfN), Durham, NC, April 26, 2024.

Kreutz, A., T. Shafer, H. Hogberg, AND M. Culbreth. Identification of training set chemicals to demonstrate the transferability of the developmental neurotoxicity in vitro battery. 5th International Conference on Developmental Neurotoxicity (DNT 5), Konstanz, GERMANY, April 07 - 10, 2024. https://doi.org/10.23645/epacomptox.25605564

Kreutz, A., X. Chang, M. Lawless, T. Shafer, J. Wambaugh, B. Wetmore, D. Allen, AND H. Hogberg. In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity: A Comparison of Physiologically Based Pharmacokinetic Models. SOT, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25400074

Shafer, T. Introduction to the EPA Developmental Neurotoxicity NAMs and Efforts to Transfer them to Outside Laboratories. Presented at Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) meeting January 2024, Virtual, NC, January 24, 2024. https://doi.org/10.23645/epacomptox.25219754

Shafer, T. Linking DNT In Vitro Battery Endpoints to Adverse Outcome Pathways using Omics Approaches. 5th International Conference on Developmental Neurotoxicity Testing (DNT5), Konstanz, GERMANY, April 07 - 10, 2024. https://doi.org/10.23645/epacomptox.25605633

Shafer, T. New Approach Methodology for Developmental Neurotoxicity: Past, Present and Future. Duke Tox & Environ Health Seminar series, Durham, NC, February 22, 2024. https://doi.org/10.23645/epacomptox.25564305

Shafer, T., T. Freudenrich, K. Wallace, M. Mayil Vahanan, AND K. Carstens. Re-testing of false negative compounds in new approach methods (NAMs) for developmental neurotoxicity screening. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25544425

Byrd, G., M. Culbreth, T. Shafer, F. Harris, AND J. Harrill. Towards an Animal Component-Free System for High Throughput Phenotypic Profiling of Human Neural Progenitor Cells. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25352776

Shafer, T. US experience for NAM Implementation for DNT. 5th International Conference on Developmental Neurotoxicity Testing (DNT5), Konstanz, GERMANY, April 07 - 10, 2024. https://doi.org/10.23645/epacomptox.25605756

Jackson, B., L. Minnema, C. Schlosser, A. Hofstra, K. Carstens, AND T. Shafer. Utility of Developmental Neurotoxicity In Vitro Battery to Address Regulatory Challenges (Syngenta SOT 24). Presented at SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25541578

Choo, S., J. Keever, J. Brown, J. Strickland, AND T. Shafer. Assaying Spontaneous Network Activity and Cellular Viability using Multi-well Microelectrode Arrays (Cell Viability Assays Book Chapter). Edition 2nd Edition, Chapter 9, Oliver Friedrich and Daniel F. Gilbert (ed.), Cell Viability Assays: Methods and Protocols (Methods in Molecular Biology, Vol 2644). Humana Press Incorporated, Totowa, NJ, , 133-154, (2023). https://doi.org/10.1007/978-1-0716-3052-5_9

Wetmore, B., K. Paul-Friedman, K. Carstens, J. Harrill, J. Wambaugh, T. Shafer, K. Houck, R. Judson, AND G. Patlewicz. Category-based toxicity and toxicokinetic evaluations of per- and polyfluoroalkyl substances (PFAS) for new approach method (NAM) application. ACS, San Francisco, CA, August 13 - 17, 2023. https://doi.org/10.23645/epacomptox.23845122

Wetmore, B., K. Friedman, K. Carstens, J. Harrill, J. Wambaugh, T. Shafer, K. Houck, R. Judson, AND G. Patlewicz. Category-based toxicity and toxicokinetic evaluations of per- and polyfluoroalkyl substances (PFAS) for new approach method (NAM) application (SERMACS 2023). SERMACS, Durham, NC, October 25 - 28, 2023. https://doi.org/10.23645/epacomptox.24790650

Carstens, K., J. Hsieh, A. Donmez, M. Scholze, K. Bartmann, T. Shafer, E. Fritsche, AND K. Paul-Friedman. Comparing the strengths and limitations of concentration-response modeling pipelines for developmental neurotoxicity new approach methods (INA 2023). International Neurotoxicology Association (INA) Meeting symposium May 2023, Durham, NC, May 21 - 25, 2023. https://doi.org/10.23645/epacomptox.23148260

Shafer, T., M. Martin, A. Carpenter, K. Friedman, AND K. Carstens. Comparisons of Microelectrode Array Acute and Network Formation In Vitro Assays for Evaluating Neurotoxicity. Society of Toxicology 62nd Annual Meeting and ToxExpo 2023, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22750703

Keever, J., A. Carpenter, J. Hedge, S. Padilla, T. Shafer, AND M. Martin. Development of a novel approach using the microelectrode array to measure neural activity and network function in larval zebrafish. Society of Toxicology 62nd Annual Meeting and ToxExpo 2023, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22652287