Science Inventory

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Shafer, T. Establishing Confidence in DNT-NAMs for Regulatory Use. JIFSAN: State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs) Workshop, College Park, MD, November 14 - 15, 2023. https://doi.org/10.23645/epacomptox.24595935

Carstens, K., T. Freudenrich, K. Wallace, S. Choo, A. Carpenter, A. Richard, G. Patlewicz, B. Wetmore, K. Friedman, AND T. Shafer. Evaluation of Per- and Poly fluoroalkyl Substances (PFAS) in vitro toxicity testing for developmental neurotoxicity (SOT 2023). Presented at Society of Toxicology 62nd Annual Meeting and ToxExpo 2023, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22714213

Carstens, K., T. Freudenrich, K. Wallace, S. Choo, A. Carpenter, M. Smeltz, M. Clifton, Matthew Henderson, A. Richard, G. Patlewicz, B. Wetmore, K. Friedman, AND T. Shafer. Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 36(3):402-419, (2023). https://doi.org/10.1021/acs.chemrestox.2c00344

Conley, J., E. Hunter, AND T. Shafer. Human Brain Organoid Model to Study Developmental Neurotoxicity. North Carolina Society of Toxicology (NCSOT) Annual Meeting, RTP, NC, September 14, 2023. https://doi.org/10.23645/epacomptox.24157887

Byrd, G., T. Freudenrich, S. Choo, M. Culbreth, T. Shafer, AND J. Harrill. Increasing the Throughput of a High-Content Imaging-Based Developmental Neurotoxicity Proliferation Assay. International Neurotoxicology Association (INA), Durham, NC, May 21 - 25, 2023. https://doi.org/10.23645/epacomptox.23148746

Shafer, T. AND M. Sachana. International efforts towards an in vitro battery of developmental neurotoxicity assays for regulatory applications. International Neurotoxicology Association, Durham, NC, May 21 - 25, 2023. https://doi.org/10.23645/epacomptox.23231873

Shafer, T. New Approach Methodologies for Developmental Neurotoxicity Hazard: A case-study with glufosinate. Food and Drug Administration Center for Food Safety and Applied Nutrition, Division of Toxicology (Virtual Presentation), RTP (Virtual), NC, February 14, 2023. https://doi.org/10.23645/epacomptox.22732418

Shafer, T. Progress in Linking DNT In Vitro Battery Endpoints to Adverse Outcome Pathways. JIFSAN: State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs) Workshop, College Park, MD, November 14 - 15, 2023. https://doi.org/10.23645/epacomptox.24595923

Shafer, T. Using New Approach Methodologies (NAMs) to Accelerate and Improve Chemical Hazard Characterization for Developmental Neurotoxicity (GRC 2023). GRC 2023 Cellular & Molecular Mechanisms of Toxicity Session: ¿New Modalities, Mechanisms, and Methods in Neurotoxicity¿, Andover, NH, August 13 - 18, 2023. https://doi.org/10.23645/epacomptox.24045468

Jackson, B., L. Minnema, Y. Wu, C. Schlosser, A. Hofstra, K. Carstens, AND T. Shafer. Utility of Developmental Neurotoxicity In Vitro Battery to Address Regulatory Challenges. 12th World Congress on Alternatives and Animal Use in the Life Sciences, Niagara Falls, CANADA, August 27 - 31, 2023. https://doi.org/10.23645/epacomptox.24058698

Jackson, B., L. Minnema, Y. Wu, C. Schlosser, A. Hofstra, K. Carstens, AND T. Shafer. Utility of Developmental Neurotoxicity In Vitro Battery to Address Regulatory Challenges (SOT of Canada). Society of Toxicology of Canada, Montreal, Quebec, CANADA, December 03 - 05, 2023. https://doi.org/10.23645/epacomptox.24347296

Choo, S., K. Wallace, T. Freudenrich, AND T. Shafer. 03222022-Electrical Impedance for non-destructive, real time measurement of neural cell viability on microelectrode Arrays (Abstract for SOT 22). Society of Toxicology 61st Annual Meeting and ToxExpo 2022, San DIego, California, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19415969

Martin, M., K. Carstens, A. Carpenter, T. Shafer, AND K. Paul-Friedman. 03272022- Comparisons of acute and network formation in vitro assays for evaluating neurotoxicity (Abstract for SOT 2022). Society of Toxicology 61st Annual Meeting, San Diego, California, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19413830

Shafer, T. A Case-Study using in vitro DNT NAMs as part of a Weight-of-Evidence (WoE) approach to decision-making for DNT. OECD WNT, Paris (online), FRANCE, May 11, 2022. https://doi.org/10.23645/epacomptox.21727874

Valdez, M., B. Langenbach, C. Mack, D. Freeborn, T. Shafer, D. Herr, AND Prasada Rao Kodavanti. An Evaluation of Neurotoxic Chemicals: ‘Omics Approach to Identify Neurotoxic Adverse Outcome Pathways. Society of Toxicology (SOT 2022) - 61st Annual Meeting and ToxExpo, San Diego, California, March 27 - 31, 2022.

Martin, M., Nancy C. Baker, W. Boyes, K. Carstens, M. Culbreth, Mary E. Gilbert, J. Harrill, J. Nyffeler, S. Padilla, K. Paul-Friedman, AND T. Shafer. An expert-driven literature review of “negative” reference chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation. NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Science Ltd, New York, NY, 93:107117, (2022). https://doi.org/10.1016/j.ntt.2022.107117

Shafer, T. Application of DNT NAMs data in Regulatory Scenarios. American Society for Cellular and Computational Toxicology, RTP, NC, October 19 - 21, 2022. https://doi.org/10.23645/epacomptox.21807096

Shafer, T. Challenges with Guideline DNT Studies Facilitate the Application of DNT NAMs by the US EPA. National Academies Committee on Variability and Relevance of Current Laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods (NAMs) for use in Human Health Risk Assessment, RTP, NC, May 12, 2022. https://doi.org/10.23645/epacomptox.19699777

Martin, M., K. Carstens, A. Carpenter, T. Shafer, AND K. Paul-Friedman. Comparisons of acute and network formation in vitro assays for evaluating neurotoxicity. Summer School on Innovative Approaches in Science 2022, Durham, NC, June 07 - 10, 2022.

Martin, M., K. Carstens, A. Carpenter, T. Shafer, AND K. Paul-Friedman. Comparisons of network formation and acute in vitro assays for evaluating neurotoxicity. Society of Toxicology 61st Annual Meeting and ToxExpo 2022, San Diego, CA, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19413830

Carstens, K., T. Shafer, AND K. Paul-Friedman. Computational approaches to integrate DNT NAMs for fit-for-purpose identification of DNT hazard (SOT March 2022). Society of Toxicology 61st Annual Meeting and ToxExpo 2022, San Diego, California, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19585813

Crofton, K., A. Bassan, M. Behl, Y. Chusak, E. Fritsche, J. Gearhart, M. Marty, M. Mumtaz, M. Pavan, P. Ruiz, T. Shafer, M. Sachana, R. Selvam, L. Stavitskaya, D. Szabo, S. Szabo, R. Tice, D. Wilson, D. Woolley, AND G. Myatt. Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 22:100223, (2022). https://doi.org/10.1016/j.comtox.2022.100223

Shafer, T. Development and Use of New Approach Methodologies for Developmental Neurotoxicity Hazard. Triangle Society for Neuroscience, RTP, NC, September 09, 2022. https://doi.org/10.23645/epacomptox.21111172

Choo, S., K. Wallace, T. Freudenrich, AND T. Shafer. Electrical Impedance for Non-Destructive, Real Time Measurement of Neural Cell Viability on Microelectrode Arrays. Society of Toxicology 61st Annual Meeting and ToxExpo 2022, San Diego, CA, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19415969

Villeneuve, D., T. Shafer, S. Padilla, J. Harrill, AND M. Jankowski. Evaluating the bioactivity of the ubiquitous tire preservative 6PPD and its quinone transformation product. National EPA Tribal Science Council, Fall 2022 Face-to-Face Meeting, Research Triangle Park, NC, December 06 - 08, 2022. https://doi.org/10.23645/epacomptox.21714164