Science Inventory

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Leonard, J., C. Stevens, K. Mansouri, D. Chang, H. Pudukodu, S. Smith, AND C. Tan. A Workflow for Identifying Metabolically Active Chemicals to Complement in vitro Toxicity Screening. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 6:71-83, (2018).

Tan, C., J. Leonard, S. Edwards, J. Teeguarden, A. Paini, AND P. Egeghy. Aggregate exposure pathways in support of risk assessment. Current Opinion in Toxicology. Elsevier BV, AMSTERDAM, Netherlands, 9:8-13, (2018).

Worley, R., J. Leonard, J. Fisher, AND C. Tan. Approaches for Increasing Acceptance of Physiologically Based Pharmacokinetic Models in Public Health Risk Assessment. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.

Tan, C., R. Worley, J. Leonard, AND J. Fisher. Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 162(2):341-348, (2018).

Tan, C., J. Leonard, J. Wambaugh, K. Isaacs, Dan Villeneuve, C. LaLone, S. Edwards, A. Williams, AND Chris Grulke. Free access platforms for integrating environmental chemical exposure and hazard information. EuroTox 2018, Brussels, BELGIUM, September 02 - 05, 2018.

Leonard, J., H. El-Masri, C. Stevens, K. Mansouri, AND C. Tan. Integrating Exposure, Pharmacokinetics, And Dosimetry With In Vitro Dose-Response Data To Evaluate Chemical Risk. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.

Chen, S., Y. Sung, E. Oyarzabal, C. Tan, J. Leonard, M. Guo, S. Li, Q. Wang, C. Chu, S. Chen, R. Lu, AND J. Hong. Physiological Concentration of Prostaglandin E2 Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway. Molecular Neurobiology. Springer, Heidelburg, Germany, 55(10):8001-8013, (2018). https://doi.org/10.1007/s12035-018-0965-4

Tan, C., J. Leonard, S. Edwards, J. Teeguarden, AND P. Egeghy. Refining the aggregate exposure pathway. Environmental Science: Processes & Impacts. RSC Publishing, Cambridge, Uk, 3(20):428-436, (2018).

Leonard, J., S. Bell, N. Oki, M. Nelms, Y. Tan, AND S. Edwards. Tiered Approaches to Incorporate the Adverse Outcome Pathway Framework into Chemical-Specific Risk-Based Decision Making. Chapter 12, Natàlia Garcia-Reyero, Cheryl A. Murphy (ed.), A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Springer International Publishing AG, Cham (ZG), Switzerland, , 235-261, (2018).

Edwards, S., C. Tan, J. Leonard, P. Egeghy, AND J. Teeguarden. A conceptual framework to advance exposure science research and complement the Adverse Outcome Pathway framework. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.

Leonard, J., D. Chang, H. El-Masri, S. Edwards, C. Stevens, K. Mansouri, P. Egeghy, AND C. Tan. A tiered approach for integrating exposure and dosimetry with in vitro dose-response data in the modern risk assessment paradigm. 254th ACS National Meeting & Exposition, Washington, DC, August 20 - 24, 2017.

Leonard, J. AND C. Tan. Complementing in vitro hazard assessment with exposure and pharmacokinetics considerations for chemical prioritization. 2017 ISES Annual Meeting, Durham, NC, October 15 - 19, 2017.

Leonard, J., C. Stevens, K. Mansouri, D. Chang, AND C. Tan. Identifying Metabolically Active Chemicals Using a Consensus Quantitative Structure Activity Model for Estrogen Receptor Binding. SOT Annual Meeting, Baltimore, MD, March 12 - 16, 2017.

Leonard, J., C. Stevens, K. Mansouri, D. Chang, AND C. Tan. Identifying Metabolically Active Chemicals Using a Consensus Quantitative Structure Activity Relationship Model for Estrogen Receptor Binding. Opentox USA 2017, Durham, NC, July 12 - 13, 2017.

Leonard, J. Integration of chemical-specific exposure and pharmacokinetic considerations with the chemical-agnostic adverse outcome pathway framework. ORD National Postdoctoral fellow forum, NC, Durham, April 11 - 12, 2017.

Paini, A., J. Leonard, T. Kliment, C. Tan, AND A. Worth. Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 90:104-115, (2017).

Oki, N., J. Leonard, M. Nelms, S. Bell, C. Tan, L. Burgoon, AND S. Edwards. Linking Environmental Exposure to Toxicity. Chapter 4, Issues in Toxicology: Computational Systems Pharmacology & Toxicology. Royal Society of Chemistry, Cambridge, Uk, , 60-88, (2017). https://doi.org/10.1039/9781782623731-00060

Mansouri, K., J. Leonard, C. Tan, M. Yoon, P. McMullen, AND R. Clewell. Scoring and ranking of metabolic trees to computationally prioritize chemicals for testing using fit-for-purpose in vitro estrogen receptor assay. OpenTox USA 2017, Durham, NC, July 12 - 13, 2017.

Moreau, M., J. Leonard, K. Phillips, J. Campbell, S. Pendse, C. Nicolas, M. Phillips, M. Yoon, C. Tan, S. Smith, H. Pudukodu, K. Isaacs, AND H. Clewell. Using exposure prediction tools to link exposure and dosimetry for risk based decisions: a case study with phthalates. 2017 SOT Annual Meeting, Baltimore, MD, March 12 - 16, 2017.

Moreau, M., J. Leonard, K. Phillips, J. Campbell, S. Pendse, C. Nicolas, M. Phillips, M. Yoon, C. Tan, S. Smith, H. Pudukodu, K. Isaacs, AND H. Clewell. Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates. CHEMOSPHERE. Elsevier Science Ltd, New York, NY, 184:1194-1201, (2017).

Lu, J., M. Goldsmith, Chris Grulke, D. Chang, J. Leonard, E. Hypes, AND C. Tan. A comprehensive physiologically based pharmacokinetic knowledgebase and web-based interface for rapid model ranking and querying. Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13 - 17, 2016.

Teeguarden, J., C. Tan, S. Edwards, P. Egeghy, J. Leonard, K. Anderson, R. Corley, A. Harding, M. Kile, S. Simonich, D. Stone, R. Tanguay, K. Waters, S. Harper, D. Williams, J. Orme-Zavaleta, AND T. Bahadori. A conceptual framework to support exposure science research and complete the source-to-outcome continuum for risk assessment. ISES 2016 Annual Meeting, Utrecht, NETHERLANDS, October 09 - 13, 2016.

Teeguarden, J., C. Tan, S. Edwards, J. Leonard, K. Anderson, R. Corley, M. Kile, S. Simonich, D. Stone, R. Tanguay, K. Waters, S. Harper, AND D. Williams. Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 50(9):4579-4586, (2016).

Leonard, J., C. Tan, M. Gilbert, K. Isaacs, AND H. El-Masri. Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-throughput In Vitro Data, High-throughput Exposure Modeling, and Physiologically-Based Pharmacokinetic/Pharmacodynamic Modeling. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 151(1):57-70, (2016).

Leonard, J., A. Sobel Leonard, D. Chang, S. Edwards, J. Lu, S. Scholle, P. Key, M. Winter, K. Isaacs, AND C. Tan. Evaluating the Impact of Uncertainties in Clearance and Exposure When Prioritizing Chemicals Screened in High-Throughput Assays. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 50(11):5961–5971, (2016).