Science Inventory

Next >>

Nichols, J., J. Arnot, AND M. Barron. Chapter 2 of Toxicology of Fishes, "Toxicokinetics in Fishes". Edition 2nd Edition, Toxicology of Fishes. CRC Press LLC, Boca Raton, FL, , N/A, (2024).

Carter, L., J. Armitage, B. Brooks, J. Nichols, AND S. Trapp. Predicting the Accumulation of Ionizable Pharmaceuticals and Personal Care Products in Aquatic and Terrestrial Organisms. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 43(3):502-512, (2024). https://doi.org/10.1002/etc.5451

Haselman, Jonathan, J. Nichols, K. Mattingly, M. Hornung, AND S. Degitz. A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in Xenopus laevis larvae. MATHEMATICAL BIOSCIENCES. Elsevier Science Ltd, New York, NY, 362:109021, (2023). https://doi.org/10.1016/j.mbs.2023.109021

Saunders, L., J. Nichols, J. Arnot, J. Armitage, AND F. Wania. An amended in vitro–in vivo extrapolation model that accounts for first pass clearance effects on chemical bioaccumulation in fish. Environmental Science: Processes & Impacts. Royal Society of Chemistry, Cambridge, Uk, 25(4):741-754, (2023). https://doi.org/10.1039/D2EM00522K

Nichols, J., P. Fitzsimmons, A. Hoffman, AND K. Wong. In vitro-in vivo extrapolation of hepatic biotransformation data for fish. III. An in-depth case study with pyrene. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 42(7):1501-1515, (2023). https://doi.org/10.1002/etc.5626

Saunders, L. AND J. Nichols. Models Used to Predict Chemical Bioaccumulation in Fish from in Vitro Biotransformation Rates Require Accurate Estimates of Blood–Water Partitioning and Chemical Volume of Distribution. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 42(1):33-45, (2023). https://doi.org/10.1002/etc.5503

Nyffeler, J., F. Harris, S. Lasee, B. Blackwell, J. Haselman, J. Nichols, G. Patlewicz, Dan Villeneuve, AND J. Harrill. Towards a High-Throughput New Approach Method for Acute Fish Toxicity: Painting the Rainbow (Trout). Society of Environmental Toxicology and Chemistry SETAC Europe 33rd Annual Meeting 2023, Dublin, N/A, IRELAND, April 30 - May 04, 2023. https://doi.org/10.23645/epacomptox.22798634

Lasee, S., J. Nyffeler, B. Blackwell, J. Harrill, F. Harris, J. Haselman, J. Nichols, AND Dan Villeneuve. Evaluating Several in vitro Disposition Models for use in High-throughput Toxicokinetic Research. Society of Environmental Toxicology and Chemistry (SETAC) North America, Pittsburgh, PA, November 13 - 17, 2022. https://doi.org/10.23645/epacomptox.21561270

Nyffeler, J., F. Harris, S. Lasee, C. Willis, G. Byrd, C. Schaupp, J. Haselman, J. Nichols, B. Blackwell, K. Flynn, Dan Villeneuve, AND J. Harrill. High-throughput ecotoxicology with a rainbow trout gill cell line (SETAC 2022). Society of Environmental Toxicology and Chemistry (SETAC) Europe 32nd Annual Meeting, Copenhagen, Virtual, DENMARK, May 15 - 19, 2022. https://doi.org/10.23645/epacomptox.19657902

Harris, F., J. Nyffeler, C. Schaupp, S. Lasee, C. Willis, J. Nichols, B. Blackwell, K. Flynn, Dan Villeneuve, AND J. Harrill. Painting the Rainbow: Expanding high-throughput chemical hazard evaluation to ecotoxicology-relevant species with a rainbow trout gill cell line. 11th annual meeting of the American Society for Cellular and Computational Toxicology (ASCCT), Chapel Hill, NC, October 19 - 21, 2022. https://doi.org/10.23645/epacomptox.21732713

Scholz, S., J. Nichols, B. Escher, G. Ankley, R. Altenburger, B. Blackwell, W. Brack, L. Burkhard, T. Collette, J. Doering, D. Ekman, K. Fay, F. Fischer, J. Hackermüller, J. Hoffman, C. Lai, D. Leuthold, D. Martinovic-Weigelt, T. Reemtsma, N. Pollesch, A. Schroeder, G. Schüürmann, AND M. Bergen. The Eco-Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 41(1):30-45, (2022). https://doi.org/10.1002/etc.5242

Mangold-Doring, A., C. Grimard, D. Green, S. Peterson, J. Nichols, N. Hogan, L. Weber, H. Hollert, M. Hecker, AND M. Brinkmann. A Novel Multispecies Toxicokinetic Modeling Approach in Support of Chemical Risk Assessment. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 55(13):9109-9118, (2021). https://doi.org/10.1021/acs.est.1c02055

Nichols, J., A. Hoffman, J. Swintek, S. Droge, AND P. Fitzsimmons. Addition of phenylmethylsulfonyl fluoride (PMSF) substantially increases the working lifetime of the trout liver S9 substrate depletion assay resulting in improved detection of low intrinsic clearance rates. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 40(1):148-161, (2021). https://doi.org/10.1002/etc.4901

Droge, S., J. Armitage, J. Arnot, P. Fitzsimmons, AND J. Nichols. Biotransformation Potential of Cationic Surfactants in Fish Assessed with Rainbow Trout Liver S9 Fractions. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 40(11):3123-3136, (2021). https://doi.org/10.1002/etc.5189

Dawson, D., B. Ingle, K. Phillips, J. Nichols, J. Wambaugh, AND R. Tornero-Velez. Designing QSARs for Parameters of High-Throughput Toxicokinetic Models Using Open-Source Descriptors. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 55(9):6505-6517, (2021). https://doi.org/10.1021/acs.est.0c06117

Dawson, D., B. Ingle, K. Phillips, J. Nichols, J. Wambaugh, AND R. Tornero-Velez. Designing QSARs for Parameters of High-Throughput Toxicokinetic Models Using Open-Source Descriptors. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 55(9):6505, (6517). https://doi.org/10.1021/acs.est.0c06117

Black, S., J. Nichols, K. Fay, S. Matten, AND S. Lynn. Evaluation and comparison of in vitro intrinsic hepatic clearance rates measured using cryopreserved hepatocytes from humans, rats, and rainbow trout. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 457:152819, (2021). https://doi.org/10.1016/j.tox.2021.152819

Saunders, L., A. Hoffman, J. Nichols, AND F. Gobas. Dietary bioaccumulation and biotransformation of hydrophobic organic sunscreen agents in rainbow trout. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 39(3):574-586, (2020). https://doi.org/10.1002/etc.4638

Keyel, E., M. Etterson, G. Niemi, D. Evers, C. DeSorbo, J. Hoffman, J. Nichols, Y. Li, AND F. Nicoletti. Feather mercury increases with feeding at higher trophic levels in two species of migrant raptors, Merlin (Falco columbarius) and Sharp-shinned Hawk (Accipiter striatus). The Condor. The Cooper Ornithological Society, Bend, OR, 122:1-17, (2020). https://doi.org/10.1093/condor/duz069

Saunders, L., P. Fitzsimmons, J. Nichols, AND F. Gobas. In vitro-in vivo extrapolation of hepatic and gastrointestinal biotrasnformation rates of hydrophobic chemicals in rainbow trout. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 228:1-12, (2020). https://doi.org/10.1016/j.aquatox.2020.105629

Haselman, Jonathan, J. Olker, P. Kosian, J. Korte, J. Swintek, J. Denny, J. Nichols, J. Tietge, M. Hornung, AND S. Degitz. Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine as a surrogate metric of metamorphic success in model amphibian Xenopus laevis. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 175(2):236-250, (2020). https://doi.org/10.1093/toxsci/kfaa036

Nichols, J., M. Ladd, A. Hoffman, AND P. Fitzsimmons. Biotransformation of pollycyclic aromatic hydrocarbons by trout liver S9 fractions: Evaluation of competitive inhibition using a substrate depletion approach. Fish Biotransformation in Bioaccumulation: Technical Workshop, sponsored by HESI, Washington, D.C, October 01 - 03, 2019.

Nichols, J., M. Ladd, A. Hoffman, AND P. Fitzsimmons. Biotransformation of polycyclic aromatic hydrocarbons by trout liver S9 fractions: Evaluation of competitive inhibition using a substrate depletion approach. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 38(12):2729-2739, (2019). https://doi.org/10.1002/etc.4595

Saunders, L., S. Fontanay, J. Nichols, AND F. Gobas. Concentration dependence of in vitro biotransformation rates of hydrophobic organic sunscreen agents in rainbow trout S9: Implications for bioaccumulation assessment. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 38(3):548-560, (2019). https://doi.org/10.1002/etc.4342

Fitzsimmons, P., A. Hoffman, K. Fay, AND J. Nichols. Allometric scaling of hepatic biotransformation in rainbow trout. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART C: TOXICOLOGY & PHARMACOLOGY . Elsevier Science Ltd, New York, NY, 214:52-60, (2018). https://doi.org/10.1016/j.cbpc.2018.08.004