Science Inventory

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Nyffeler, J., F. Harris, S. Lasee, B. Blackwell, J. Haselman, J. Nichols, G. Patlewicz, Dan Villeneuve, AND J. Harrill. Towards a High-Throughput New Approach Method for Acute Fish Toxicity: Painting the Rainbow (Trout). Society of Environmental Toxicology and Chemistry SETAC Europe 33rd Annual Meeting 2023, Dublin, N/A, IRELAND, April 30 - May 04, 2023. https://doi.org/10.23645/epacomptox.22798634

Harris, F., J. Nyffeler, S. Lasee, B. Blackwell, Dan Villeneuve, AND J. Harrill. Using high-throughput phenotypic profiling to screen chemicals in a rainbow trout gill cell line (RTgill-W1). Society of Toxicology 62nd Annual Meeting and ToxExpo 2023, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22753823

Harrill, A., J. Nyffeler, C. Willis, I. Daou, C. Michelon, D. You, T. Choi, M. Culbreth, J. Hsieh, AND J. Harrill. A population screen of chemical toxicity using high-throughput phenotypic profiling (HTPP) in Diversity Outbred neural progenitor cells. Future Tox 5, Chapel Hill, NC, May 10 - 11, 2022. https://doi.org/10.23645/epacomptox.19896313

Harrill, A., J. Nyffeler, C. Willis, I. Daou, C. Michelon, D. You, T. Choi, M. Culbreth, J. Hsieh, AND J. Harrill. A population screen of chemical toxicity using high-throughput phenotypic profiling (HTPP) in Diversity Outbred neural progenitor cells. Society of Toxicology 61st Annual Meeting and ToxExpo 2022, San Diego, CA, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19404047

Martin, M., Nancy C. Baker, W. Boyes, K. Carstens, M. Culbreth, Mary E. Gilbert, J. Harrill, J. Nyffeler, S. Padilla, K. Paul-Friedman, AND T. Shafer. An expert-driven literature review of “negative” reference chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation. NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Science Ltd, New York, NY, 93:107117, (2022). https://doi.org/10.1016/j.ntt.2022.107117

Byrd, G., A. Goldstein-Plesser, J. Nyffeler, C. Willis, A. Fisher, W. Boyes, AND J. Harrill. Assessing the Effects of Silver Nanoparticles on ARPE-19 Cells via Imaging-Based High Throughput Phenotypic Profiling. American Society for Cellular and Computational Toxicology (ASCCT) Annual Meeting, Chapel Hill, NC, October 19 - 21, 2022. https://doi.org/10.23645/epacomptox.23504424

Nyffeler, J., C. Willis, Danielle Harris, L. Taylor, R. Judson, L. Everett, AND J. Harrill. Combining phenotypic profiles and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: retinoic acid as an example. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 444:116032, (2022). https://doi.org/10.1016/j.taap.2022.116032

Lasee, S., J. Nyffeler, B. Blackwell, J. Harrill, F. Harris, J. Haselman, J. Nichols, AND Dan Villeneuve. Evaluating Several in vitro Disposition Models for use in High-throughput Toxicokinetic Research. Society of Environmental Toxicology and Chemistry (SETAC) North America, Pittsburgh, PA, November 13 - 17, 2022. https://doi.org/10.23645/epacomptox.21561270

Willis, C., J. Nyffeler, AND J. Harrill. Examining the Effects of Reference Chemicals Across a Variety of Human-Derived Cell Lines Using High-Throughput Phenotypic Profiling (HTPP). Society of Toxicology 61st Annual Meeting and ToxExpo 2022, San Diego, CA, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19394228

Harris, F., J. Nyffeler, R. Brockway, C. Willis, AND J. Harrill. High-Throughput Phenotypic Profiling (HTPP) of HepaRG Cells Using the Cell Painting Assay (NCSOT Jan 2022). North Carolina Society of Toxicology 2022 annual meeting, Durham (Virtual), North Carolina, January 19, 2022. https://doi.org/10.23645/epacomptox.19586062

Nyffeler, J., F. Harris, S. Lasee, C. Willis, G. Byrd, C. Schaupp, J. Haselman, J. Nichols, B. Blackwell, K. Flynn, Dan Villeneuve, AND J. Harrill. High-throughput ecotoxicology with a rainbow trout gill cell line (SETAC 2022). Society of Environmental Toxicology and Chemistry (SETAC) Europe 32nd Annual Meeting, Copenhagen, Virtual, DENMARK, May 15 - 19, 2022. https://doi.org/10.23645/epacomptox.19657902

Nyffeler, J., F. Harris, C. Willis, K. Paul-Friedman, AND J. Harrill. High-throughput phenotypic profiling for grouping of 68 conazoles (SOT2022). Society of Toxicology 61st Annual Meeting and ToxExpo 2022, San Diego, CA, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19658562

Everett, L., J. Harrill, R. Judson, I. Shah, J. Nyffeler, AND A. Middleton. Integration & Analysis of High-Throughput Assays in Next Generation Risk Assessment. 16th International Congress of Toxicology (IUTOX ICT 2022), MaastrichtN, September 18 - 22, 2022. https://doi.org/10.23645/epacomptox.21120187

Shah, I., J. Bundy, B. Chambers, L. Everett, D. Haggard, J. Harrill, R. Judson, J. Nyffeler, AND G. Patlewicz. Navigating Transcriptomic Connectivity Mapping Workflows to Link Chemicals with Bioactivities. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 35(11):1929-1949, (2022). https://doi.org/10.1021/acs.chemrestox.2c00245

Culbreth, M., J. Nyffeler, C. Willis, AND J. Harrill. Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity Screening . Frontiers in Toxicology. Frontiers, Lausanne, Switzerland, 3:803987, (2021). https://doi.org/10.3389/ftox.2021.803987

Culbreth, M., J. Nyffeler, C. Willis, AND J. Harrill. Optimization of an animal-component free system for high-throughput phenotypic profiling of human neural progenitor cells (SOT 2022). Society of Toxicology (SOT) Annual Meeting 2022, San Diego, CA, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19398461

Harris, F., J. Nyffeler, C. Schaupp, S. Lasee, C. Willis, J. Nichols, B. Blackwell, K. Flynn, Dan Villeneuve, AND J. Harrill. Painting the Rainbow: Expanding high-throughput chemical hazard evaluation to ecotoxicology-relevant species with a rainbow trout gill cell line. 11th annual meeting of the American Society for Cellular and Computational Toxicology (ASCCT), Chapel Hill, NC, October 19 - 21, 2022. https://doi.org/10.23645/epacomptox.21732713

Martin, M., Nancy C. Baker, W. Boyes, K. Carstens, M. Culbreth, M. Gilbert, J. Harrill, J. Nyffeler, S. Padilla, K. Paul-Friedman, AND T. Shafer. An expert-driven literature review of “negative” reference chemicals for developmental neurotoxicity (DNT) assay evaluation. Society of Toxicology 2021 Virtual Annual Meeting, Virtual, North Carolina, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.14226326

Nyffeler, J. Application of Cell Painting at the Center for Computation Toxicology and Exposure (Talk for Johnson & Johnson). Invited Presentation to the high-content imaging group at Johnson & Johnson, virtual, NC, March 10, 2021. https://doi.org/10.23645/epacomptox.16661176

Nyffeler, J. AND J. Harrill. Application of Cell Painting, an Imaging-Based High Throughput Phenotypic Profiling Assay for Bioactivity Screening of Environmental Chemicals (SOT 2021). Society of Toxicology Virtual Annual Meeting 2021, virtual, NC, March 15 - 25, 2021. https://doi.org/10.23645/epacomptox.16799392

Nyffeler, J., D. Haggard, C. Willis, Woodrow Setzer, R. Judson, K. Paul-Friedman, L. Everett, AND J. Harrill. Comparison of Approaches for Determining Bioactivity Hits from High-Dimensional Profiling Data. SLAS Discovery. SAGE Publications, THOUSAND OAKS, CA, 26(2):292-308, (2021). https://doi.org/10.1177/2472555220950245

Nyffeler, J., C. Willis, G. Patlewicz, I. Shah, AND J. Harrill. High-throughput phenotypic profiling to inform putative mode of action for environmental chemicals (QSAR 2021). QSAR 2021 International Workshop on QSAR in Environmental and Health Sciences, Virtual, NC, June 07 - 10, 2021. https://doi.org/10.23645/epacomptox.15073968

Nyffeler, J., C. Willis, M. Culbreth, Richard E. Brockway, L. Everett, G. Patlewicz, I. Shah, D. Chang, J. Wambaugh, K. Paul-Friedman, AND J. Harrill. High-throughput phenotypic profiling within the NAMs-based, tiered hazard evaluation strategy at the U.S. Environmental Protection Agency (EuroTox 2021). EUROTOX congress 2021, virtual, NC, September 26 - October 01, 2021. https://doi.org/10.23645/epacomptox.16838164

Nyffeler, J., C. Willis, G. Patlewicz, D. Chang, I. Shah, AND J. Harrill. Identifying putative mode-of-actions for environmental chemicals using high-throughput phenotypic profiling (WC11). 11th World Conference on Alternatives and Animal Use in the Life Science (WC11), Virtual, NC, NETHERLANDS, August 23 - September 02, 2021. https://doi.org/10.23645/epacomptox.16837921

Nyffeler, J. Imaging-based phenotypic profiling for high-throughput chemical screening at the U.S. Environmental Protection Agency (UFZ Webinar). Webinar to German environmental research center (UFZ) Leibzig, virtual, GERMANY, December 07, 2021. https://doi.org/10.23645/epacomptox.17212607