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Records 1 to 25 of 35 records from [ORD-NHEERL] from author Christopher Eklund

2020
Evans, M., C. Eklund, D. williams, Y. Sey, AND J. Simmons. Global Optimization of the Michaelis-Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 32(3):97-109, (2020). https://doi.org/10.1080/08958378.2020.1742818
2018
Eklund, C., M. Evans, H. Yang, Y. Sey, AND J. Simmons. A Physiologically-Based Pharmacokinetic (PBPK) Model With Metabolic Interactions of Chloroform (CHCL3) and Trichloroethylene. Society of Toxicology, San Antonio, TX, March 11 - 15, 2018.
Kenyon, E., C. Eklund, J. Simmons, AND R. Pegram. FACTORS INFLUENCING PREDICTION OF BROMODICHLOROMETHANE (BDCM) IN EXHALED BREATH: FURTHER EVALUATION OF A HUMAN BDCM PBPK MODEL. Society of Toxicology, San Antonio, Texas, March 11 - 15, 2018.
2017
Kenyon, E., C. Eklund, R. Pegram, AND J. Simmons. PBPK-MODEL ESTIMATES OF BROMODICHLOROMETHANE (BDCM) DELIVERY TO THE HUMAN URINARY BLADDER. Gordon Research Conference, Mt Holyoke, Massachusetts, July 30 - August 04, 2017.
2016
Conolly, R., W. Cheng, C. Eklund, J. Samet, P. Wages, K. Lavrich, AND S. Bhattacharya. Agent-Based Computational Modeling of Cell Culture: Understanding Dosimetry In Vitro as Part of In Vitro to In Vivo Extrapolation. SOT 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13 - 17, 2016.
Conolly, R., W. Cheng, C. Eklund, J. Samet, P. Wages, K. Lavrich, S. Bhattacharya, K. Grode, T. Knudsen, AND S. Hunter. Agent-Based Computational Modeling to Examine How Individual Cell Morphology Affects Dosimetry. BOSC CSS, RTP, NC, November 16 - 18, 2016.
Kenyon, E., T. Leavens, C. Eklund, AND R. Pegram. Development and Application of a Human PBPK Model for Bromodichloromethane (BDCM) to Investigate Impacts of Multi-Route Exposure. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 36(9):1095-1111, (2015).
Sawyer, M., Marina V. Evans, C. Wilson, L. Beesley, L. Leon, C. Eklund, E. Croom, AND R. Pegram. Development of a Human Physiologically Based Pharmacokinetics (PBPK) Model For Dermal Permeability for Lindane. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, 14(245):pp106-109, (2016).
Kenyon, E., C. Eklund, J. Simmons, AND R. Pegram. PBPK-MODEL ESTIMATES OF BROMODICHLOROMETHANE (BDCM) DISTRIBUTION IN URINE AND BLADDER TISSUE. Society of Toxicology, New Orleans, LA, March 12 - 17, 2016.
Kenyon, E., C. Eklund, J. Lipscomb, AND R. Pegram. The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM). Toxicology Mechanisms and Methods. Taylor & Francis, Inc., Philadelphia, PA, 26(8):620-626, (2016).
2015
Croom, E., Tim Shafer, M. Evans, W. Mundy, C. Eklund, A. Johnstone, C. Mack, AND R. Pegram. Improving In Vitro to In Vivo Extrapolation by Incorporating Toxicokinetic Measurements: A Case Study of Lindane-Induced Neurotoxicity. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 283(1):9-19, (2015).
2012
KENYON, E. M., R. A. PEGRAM, C. R. EKLUND, AND J. C. LIPSCOMB. COMPARISON OF IN VIVO DERIVED AND SCALED IN VITRO METABOLIC RATE CONSTANTS FOR SOME VOLATILE ORGANIC COMPOUNDS (VOCS). Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.
EVANS, M. V., W. Cuello, J. Jessee, M. Venecek, M. Sawyer, AND C. R. EKLUND. Physiologically-based pharmacokinetic (PBPK) modeling to explore potential metabolic pathways of bromochloromethane in rats. Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.
2011
Cuello, W., J. Simpson, M. Sawyer, M. V. EVANS, M. Sawyer, AND C. R. EKLUND. Physiologically-based pharmacokinetic (PBPK) modeling of metabolic pathways of bromochloromethane. Presented at Research Experience for Undergraduates (REU) Meeting, NC STATE UNIVERSITY, Raleigh, NC, May 31 - August 04, 2011.
2010
EKLUND, C. R., M. V. EVANS, AND J. E. SIMMONS. Application of physiologically based pharmacokinetic (PBPK) model of trichloroethylene in rats for estimation of internal dose. Presented at Society of Toxicology 49th Annual meeting, Salt Lake City, UT, March 07 - 11, 2010.
KENYON, E. M., W. M. OSHIRO, C. R. EKLUND, C. Gordon, Q. T. KRANTZ, AND P. J. BUSHNELL. Modeling the toxicokinetics of 24-hour toluene exposure in rats, impact of activity patterns and enzyme induction. Presented at Society of Toxicology 49th Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.
2009
BENIGNUS, V. A., P. Bushnell, W. K. BOYES, C. R. EKLUND, AND E. M. KENYON. Neurobehavorial effects of acute exposure to four solvents: meta-abalyses. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 109(2):295-305, (2009).
2008
KENYON, E. M., V. A. BENIGNUS, C. R. EKLUND, J. W. HIGHFILL, W. M. OSHIRO, T. E. SAMSAM, AND P. J. BUSHNELL. MODELING THE TOXICOKINETICS OF INHALED TOLUENE IN RATS: THE IMPACT OF CONDITIONING AND PHYSICAL ACTIVITY. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. Taylor & Francis, Inc., Philadelphia, PA, 71(4):249-65, (2008).
2007
KENYON, E. M., V. A. BENIGNUS, C. R. EKLUND, AND P. J. BUSHNELL. MODELING THE TOXICOKINETICS OF INHALED TOLUENE IN RATS: THE IMPACT OF FEEDING STATUS, PHYSICAL ACTIVITY AND STRAIN. Presented at Society of Toxicology Annual Meeting, Charlotte, NC, March 25 - 29, 2007.
2006
KENYON, E. M., M. F. HUGHES, C. R. EKLUND, AND M. V. EVANS. EVALUATION OF INTERSPECIES DIFFERENCES IN PHARMACOKINETICS (PK) USING A PBPK MODEL FOR THE PESTICIDE DIMETHYLARSINIC ACID (DMAV) . Presented at 45th Annual Society of Toxicology Meeting 2006, San Diego, CA, March 05 - 09, 2006.
EKLUND, C. R., W. K. BOYES, J. E. SIMMONS, AND M. V. EVANS. THE EFFECT OF UNCERTAINTY FACTOR PLACEMENT IN A PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL OF TRICHLOROETHYLENE (TCE) FOR ACUTE EXPOSURE GUIDELINE LEVELS (AEGL). . Presented at 45th Annual Society of Toxicology Meeting 2006, San Diego, CA, March 05 - 09, 2006.
2005
Kenyon, E M., M F. Hughes, C R. Eklund, AND M V. Evans. A PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODEL FOR THE PESTICIDE MONOMETHYLARSONIC ACID (MMA). Presented at Society of Toxicology Annual Meeting, New Orleans, LA, March 06 - 10, 2005.
Boyes, W K., P J. Bushnell, J E. Simmons, C Eklund, V A. Benignus, AND P. Janssen. APPLICATIONS OF DOSIMETRY MODELING TO ASSESSING NEUROTOXIC RISK. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. Elsevier Science BV, Amsterdam, Netherlands, 19(3):599-605, (2005).
Bushnell, P J., T J. Shafer, A. S. Bale, W K. Boyes, J E. Simmons, C Eklund, AND T. L. Jackson. DEVELOPING AN EXPOSURE-DOSE-RESPONSE MODEL FOR THE ACUTE NEUROTOXICITY OF ORGANIC SOLVENTS: OVERVIEW AND PROGRESS ON IN VITRO MODELS AND DOSIMETRY. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. Elsevier Online, New York, NY, 19:607-614, (2005).