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Records 1 to
25
of 45 records from author Christopher Eklund
2023
Kenyon, E., Michael Wright, R. Shaffer, Tom Luben, AND C. Eklund. Development of Uptake Factors for Trihalomethanes (THMs) Using a Multi-Route Human Physiologically Based Pharmacokinetic (PBPK) Model. SOT, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22144163
Kenyon, E., J. Wright, R. Shaffer, T. Luben, AND C. Eklund. Development of Uptake Factors for Water Use Activities for Trihalomethanes (THMs) Using a Multi-Route Human Physiologically Based Pharmacokinetic (PBPK) Model. Gordon Research Conference, South Hadley, MA, July 30 - August 04, 2023. https://doi.org/10.23645/epacomptox.23739093
2022
Fisher, H., M. Evans, C. Eklund, Dan Vallero, A. Bunge, AND E. Hubal. Dermal Absorption Model. ISES, Lisbon, PORTUGAL, September 25 - 29, 2022. https://doi.org/10.23645/epacomptox.21190201
Fisher, H., M. Evans, A. Bunge, Dan Vallero, C. Eklund, AND E. Hubal. Dermal absorption modeling for in-vitro experiments using human skin for fragrance chemicals - approach and challenges. Society of Toxicology, San Diego, CA, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19401218
2021
Kenyon, E., C. Eklund, J. Simmons, AND R. Pegram. Factors Influencing Prediction of Bromodichloromethane (BDCM) in Exhaled Breath. Society of Toxicology 2021 Virtual Annual Meeting, Virtual, NC, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.17952557
2020
Kenyon, E., C. Eklund, R. Pegram, AND J. Lipscomb. Comparison of In Vivo Derived and Scaled In Vitro Metabolic Rate Constants for Several Volatile Organic Compounds (VOCs). TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 69:105002, (2020). https://doi.org/10.1016/j.tiv.2020.105002
Evans, M., C. Eklund, D. williams, Y. Sey, AND J. Simmons. Global Optimization of the Michaelis-Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 32(3):97-109, (2020). https://doi.org/10.1080/08958378.2020.1742818
Eklund, C., E. Kenyon, R. Pegram, AND J. Simmons. Liter-Equivalence Extrapolation for Four Trihalomethanes (THMs): What Drink Would It Take to Get the Same Internal Dose? Society of Toxicology, Anaheim, California, March 15 - 19, 2020.
Eklund, C., E. Kenyon, R. Pegram, AND J. Simmons. Liter-Equivalence Extrapolation for Four Trihalomethanes (THMs): What Drink Would It Take to Get the Same Internal Dose? (SOT 2020). Society of Toxicology, Anaheim, California, March 15 - 19, 2020. https://doi.org/10.23645/epacomptox.12551309
2018
Eklund, C., M. Evans, H. Yang, Y. Sey, AND J. Simmons. A Physiologically-Based Pharmacokinetic (PBPK) Model With Metabolic Interactions of Chloroform (CHCL3) and Trichloroethylene. Society of Toxicology, San Antonio, TX, March 11 - 15, 2018.
Kenyon, E., C. Eklund, J. Simmons, AND R. Pegram. FACTORS INFLUENCING PREDICTION OF BROMODICHLOROMETHANE (BDCM) IN EXHALED BREATH: FURTHER EVALUATION OF A HUMAN BDCM PBPK MODEL. Society of Toxicology, San Antonio, Texas, March 11 - 15, 2018.
2017
Kenyon, E., C. Eklund, R. Pegram, AND J. Simmons. PBPK-MODEL ESTIMATES OF BROMODICHLOROMETHANE (BDCM) DELIVERY TO THE HUMAN URINARY BLADDER. Gordon Research Conference, Mt Holyoke, Massachusetts, July 30 - August 04, 2017.
2016
Conolly, R., W. Cheng, C. Eklund, J. Samet, P. Wages, K. Lavrich, AND S. Bhattacharya. Agent-Based Computational Modeling of Cell Culture: Understanding Dosimetry In Vitro as Part of In Vitro to In Vivo Extrapolation. SOT 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13 - 17, 2016.
Conolly, R., W. Cheng, C. Eklund, J. Samet, P. Wages, K. Lavrich, S. Bhattacharya, K. Grode, T. Knudsen, AND S. Hunter. Agent-Based Computational Modeling to Examine How Individual Cell Morphology Affects Dosimetry. BOSC CSS, RTP, NC, November 16 - 18, 2016.
Kenyon, E., T. Leavens, C. Eklund, AND R. Pegram. Development and Application of a Human PBPK Model for Bromodichloromethane (BDCM) to Investigate Impacts of Multi-Route Exposure. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 36(9):1095-1111, (2015).
Sawyer, M., Marina V. Evans, C. Wilson, L. Beesley, L. Leon, C. Eklund, E. Croom, AND R. Pegram. Development of a Human Physiologically Based Pharmacokinetics (PBPK) Model For Dermal Permeability for Lindane. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, 14(245):pp106-109, (2016).
Kenyon, E., C. Eklund, J. Simmons, AND R. Pegram. PBPK-MODEL ESTIMATES OF BROMODICHLOROMETHANE (BDCM) DISTRIBUTION IN URINE AND BLADDER TISSUE. Society of Toxicology, New Orleans, LA, March 12 - 17, 2016.
Kenyon, E., C. Eklund, J. Lipscomb, AND R. Pegram. The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM). Toxicology Mechanisms and Methods. Taylor & Francis, Inc., Philadelphia, PA, 26(8):620-626, (2016).
2015
Croom, E., Tim Shafer, M. Evans, W. Mundy, C. Eklund, A. Johnstone, C. Mack, AND R. Pegram. Improving In Vitro to In Vivo Extrapolation by Incorporating Toxicokinetic Measurements: A Case Study of Lindane-Induced Neurotoxicity. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 283(1):9-19, (2015).
2012
KENYON, E. M., R. A. PEGRAM, C. R. EKLUND, AND J. C. LIPSCOMB. COMPARISON OF IN VIVO DERIVED AND SCALED IN VITRO METABOLIC RATE CONSTANTS FOR SOME VOLATILE ORGANIC COMPOUNDS (VOCS). Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.
EVANS, M. V., W. Cuello, J. Jessee, M. Venecek, M. Sawyer, AND C. R. EKLUND. Physiologically-based pharmacokinetic (PBPK) modeling to explore potential metabolic pathways of bromochloromethane in rats. Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.
2011
Cuello, W., J. Simpson, M. Sawyer, M. V. EVANS, M. Sawyer, AND C. R. EKLUND. Physiologically-based pharmacokinetic (PBPK) modeling of metabolic pathways of bromochloromethane. Presented at Research Experience for Undergraduates (REU) Meeting, NC STATE UNIVERSITY, Raleigh, NC, May 31 - August 04, 2011.
2010
EKLUND, C. R., M. V. EVANS, AND J. E. SIMMONS. Application of physiologically based pharmacokinetic (PBPK) model of trichloroethylene in rats for estimation of internal dose. Presented at Society of Toxicology 49th Annual meeting, Salt Lake City, UT, March 07 - 11, 2010.
KENYON, E. M., W. M. OSHIRO, C. R. EKLUND, C. Gordon, Q. T. KRANTZ, AND P. J. BUSHNELL. Modeling the toxicokinetics of 24-hour toluene exposure in rats, impact of activity patterns and enzyme induction. Presented at Society of Toxicology 49th Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.
2009
BENIGNUS, V. A., P. Bushnell, W. K. BOYES, C. R. EKLUND, AND E. M. KENYON. Neurobehavorial effects of acute exposure to four solvents: meta-abalyses. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 109(2):295-305, (2009).