Office of Research and Development Publications

National Exposure Research Laboratory (NERL) Research Publications

Records 1 to 25 of 27 records from ORD-NERL published between 02/19/2014 and 02/19/2019 from author Jeremy Leonard

Chen, S., Y. Sung, E. Oyarzabal, C. Tan, J. Leonard, M. Guo, S. Li, Q. Wang, C. Chu, S. Chen, R. Lu, AND J. Hong. Physiological Concentration of Prostaglandin E2 Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway. Molecular Neurobiology. Springer, Heidelburg, Germany, 55(10):8001-8013, (2018). https://doi.org/10.1007/s12035-018-0965-4
Tan, C., J. Leonard, J. Wambaugh, K. Isaacs, Dan Villeneuve, C. LaLone, S. Edwards, A. Williams, AND Chris Grulke. Free access platforms for integrating environmental chemical exposure and hazard information. EuroTox 2018, Brussels, BELGIUM, September 02 - 05, 2018.
Leonard, J., C. Stevens, K. Mansouri, D. Chang, H. Pudukodu, S. Smith, AND C. Tan. A Workflow for Identifying Metabolically Active Chemicals to Complement in vitro Toxicity Screening. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 6:71-83, (2018).
Tan, C., J. Leonard, S. Edwards, J. Teeguarden, A. Paini, AND P. Egeghy. Aggregate exposure pathways in support of risk assessment. Current Opinion in Toxicology. Elsevier BV, AMSTERDAM, Netherlands, 9:8-13, (2018).
Tan, C., R. Worley, J. Leonard, AND J. Fisher. Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 162(2):341-348, (2018).
Tan, C., J. Leonard, S. Edwards, J. Teeguarden, AND P. Egeghy. Refining the aggregate exposure pathway. Environmental Science: Processes & Impacts. RSC Publishing, Cambridge, Uk, 3(20):428-436, (2018).
Leonard, J., H. El-Masri, C. Stevens, K. Mansouri, AND C. Tan. Integrating Exposure, Pharmacokinetics, And Dosimetry With In Vitro Dose-Response Data To Evaluate Chemical Risk. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.
Worley, R., J. Leonard, J. Fisher, AND C. Tan. Approaches for Increasing Acceptance of Physiologically Based Pharmacokinetic Models in Public Health Risk Assessment. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.
Leonard, J. AND C. Tan. Complementing in vitro hazard assessment with exposure and pharmacokinetics considerations for chemical prioritization. 2017 ISES Annual Meeting, Durham, NC, October 15 - 19, 2017.
Paini, A., J. Leonard, T. Kliment, C. Tan, AND A. Worth. Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 90:104-115, (2017).
Leonard, J., D. Chang, H. El-Masri, S. Edwards, C. Stevens, K. Mansouri, P. Egeghy, AND C. Tan. A tiered approach for integrating exposure and dosimetry with in vitro dose-response data in the modern risk assessment paradigm. 254th ACS National Meeting & Exposition, Washington, DC, August 20 - 24, 2017.
Leonard, J., C. Stevens, K. Mansouri, D. Chang, AND C. Tan. Identifying Metabolically Active Chemicals Using a Consensus Quantitative Structure Activity Relationship Model for Estrogen Receptor Binding. Opentox USA 2017, Durham, NC, July 12 - 13, 2017.
Mansouri, K., J. Leonard, C. Tan, M. Yoon, P. McMullen, AND R. Clewell. Scoring and ranking of metabolic trees to computationally prioritize chemicals for testing using fit-for-purpose in vitro estrogen receptor assay. OpenTox USA 2017, Durham, NC, July 12 - 13, 2017.
Moreau, M., J. Leonard, K. Phillips, J. Campbell, S. Pendse, C. Nicolas, M. Phillips, M. Yoon, C. Tan, S. Smith, H. Pudukodu, K. Isaacs, AND H. Clewell. Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates. CHEMOSPHERE. Elsevier Science Ltd, New York, NY, 184:1194-1201, (2017).
Leonard, J. Integration of chemical-specific exposure and pharmacokinetic considerations with the chemical-agnostic adverse outcome pathway framework. ORD National Postdoctoral fellow forum, NC, Durham, April 11 - 12, 2017.
Leonard, J., C. Stevens, K. Mansouri, D. Chang, AND C. Tan. Identifying Metabolically Active Chemicals Using a Consensus Quantitative Structure Activity Model for Estrogen Receptor Binding. SOT Annual Meeting, Baltimore, MD, March 12 - 16, 2017.
Moreau, M., J. Leonard, K. Phillips, J. Campbell, S. Pendse, C. Nicolas, M. Phillips, M. Yoon, C. Tan, S. Smith, H. Pudukodu, K. Isaacs, AND H. Clewell. Using exposure prediction tools to link exposure and dosimetry for risk based decisions: a case study with phthalates. 2017 SOT Annual Meeting, Baltimore, MD, March 12 - 16, 2017.
Teeguarden, J., C. Tan, S. Edwards, P. Egeghy, J. Leonard, K. Anderson, R. Corley, A. Harding, M. Kile, S. Simonich, D. Stone, R. Tanguay, K. Waters, S. Harper, D. Williams, J. Orme-Zavaleta, AND T. Bahadori. A conceptual framework to support exposure science research and complete the source-to-outcome continuum for risk assessment. ISES 2016 Annual Meeting, Utrecht, NETHERLANDS, October 09 - 13, 2016.
Tan, C., H. El-Masri, S. Edwards, J. Leonard, S. Suarez, AND K. Fay. Integration of chemical-specific exposure and pharmacokinetic information with the chemical-agnostic AOP framework to support high throughput risk assessment. Chemical Safety for Sustainability Subcommittee Meeting, Durham, NC, November 16 - 17, 2016.
Teeguarden, J., C. Tan, S. Edwards, J. Leonard, K. Anderson, R. Corley, M. Kile, S. Massey Simonich, D. Stone, R. Tanguay, K. Waters, S. Harper, AND D. Williams. Expanding on Successful Concepts, Models, and Organization. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 50(17):8921–8922, (2016).
Tan, C., S. Edwards, J. Teeguarden, P. Egeghy, AND J. Leonard. The Aggregate Exposure Pathway (AEP): A conceptual framework for advancing exposure science research and transforming risk assessment. SETAC North America 37th Annual Meeting, Orlando, FL, November 06 - 10, 2016.
Leonard, J., A. Sobel Leonard, D. Chang, S. Edwards, J. Lu, S. Scholle, P. Key, M. Winter, K. Isaacs, AND C. Tan. Evaluating the Impact of Uncertainties in Clearance and Exposure When Prioritizing Chemicals Screened in High-Throughput Assays. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 50(11):5961–5971, (2016).
Teeguarden, J., C. Tan, S. Edwards, J. Leonard, K. Anderson, R. Corley, M. Kile, S. Simonich, D. Stone, R. Tanguay, K. Waters, S. Harper, AND D. Williams. Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 50(9):4579-4586, (2016).
Tan, C., J. Leonard, S. Scholle, M. Winter, P. Key, J. Lu, AND D. Chang. Evaluating the Value of Augmenting In Vitro Hazard Assessment with Exposure and Pharmacokinetics Considerations for Chemical Prioritization. Society of Toxicology Conf, New Orleans, LA, March 13 - 17, 2016.
Leonard, J., R. Goldsmith, D. Chang, AND Yumei Tan. A workflow to investigate exposure and pharmacokinetic influences on high-throughput in vitro chemical screening based on adverse outcome pathways, OpenTox USA 2015 Poster. OpenTox USA 2015, Baltimore, MD, February 10 - 12, 2015.