Office of Research and Development Publications

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Records 1 to 25 of 1666

20190622 - Application of AOPs to Developmental Outcomes (Teratology Society) (PRESENTATION)
AOP-based ontologies provide the necessary structure for quantitative prediction of cellular and tissue responses to molecular perturbation(s). For DevTox, this can be demonstrated by an AOP framework for embryonic vascular disruption represented in the OECD AOP-KB (Aop43). Becau...
20190521 - The EPA CompTox Chemicals Dashboard – An integration hub for data supporting computational toxicology (NURA) (PRESENTATION)
The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This involves computational and data-driven app...
20190520 - Fusing Exposure Data and Models to Reduce Uncertainty (PRESENTATION)
Prioritizing the thousands of chemicals that occur in commerce with respect to potential risk posed to the public health requires tools that can estimate exposure from limited information. Human exposure biomarker data indicates that consumer products are a primary source of chem...
20190310 - Read-across: From theory to practical application (SOT) (PRESENTATION)
Read-across is a well-established data gap filling technique used within analogue and category approaches. There are several steps in the category workflow starting from analogue identification, analogue evaluation, data gap filling through to uncertainty assessment. There are a ...
20190502 - Use of GenRA to Assist in Read-Across (Cal EPA) (PRESENTATION)
Read-across describes the method of filling a data gap whereby a chemical with existing data values is used to make a prediction for a ‘similar’ chemical. A target chemical is a chemical which has a data gap that needs to be filled i.e. the subject of the read-across....
20190502 - PFAS Prioritisation for Targeted Testing (Cal EPA) (PRESENTATION)
What are Per-and Polyfluoroalkyl Substances (PFAS)? Thousands of PFAS are associated with the production of industrial and consumer products. They are a concern due to: 1) Known or suspected toxicity, especially for PFOS and PFOA, 2) Bioaccumulation, 3) Long half lives (e.g., sev...
20190502 - Approaches to Hazard and Dose-Response Assessment of PFAS: PFBS Example (CalEPA) (PRESENTATION)
Depending on who you talk to, there are anywhere from 20K to >80K chemicals currently in the environment/commerce; several thousand are PFAS compounds. Collectively, across our global community of toxicology and risk assessment practice, only a small fraction of those chemical...
20190502 - U.S. EPA’s Use of Read-Across in Provisional Peer-Reviewed Toxicity Value Assessments (Cal EPA) (PRESENTATION)
This presentation will begin with 1) What are Provisional Peer-Reviewed Toxicity Values (PPRTVs)?, 2) Advent of Appendix Screening Values: Expert-Driven Read Across, 3) n-Heptane example, 4) p,p’-DDD example (integrating ToxCast bioactivity), 5) Limitations and challenges.
20190426 - Profile Building, Research Sharing and Data Proliferation using Social Media Tools for Scientists (NLTO) (PRESENTATION)
Who markets your work? If not you, then who? The presenter hopes to encourage people in the “era of participation”, provide an overview of some tools available, share some stories, statistics and strategies, and encourage researchers to “share for the sake of co...
20190405 - US-EPA CompTox Chemicals Dashboard: Bioactivity Data for Endocrine Assays (EDSP) (PRESENTATION)
EPA’s National Center for Computational Toxicology is developing automated workflows for curating large databases within the DSSTox project and for providing accurate linkages of data to chemical structures, exposure, and hazard data. The data are made available via the EPA...
20190513 - Future of Reproductive and Developmental Toxicity Testing: computational and organoids (Dev Tox Course) (PRESENTATION)
This joint American College of Toxicology/Teratology Society courseon Practical Reproductive and Developmental Toxicology is designed to provide a basic understanding in reproductive and developmental biology and principles of various testing approaches for reproductive and devel...
20190415 - Computational Environmental Sciences and Toxicology (PRESENTATION)
We would like to know more about the risk posed by thousands of chemicals in the environment – which ones should we start with? High throughput screening (HTS) provides one path forward for identifying potential hazard, but the real world is complicated by toxicokinetics, m...
20190409 - Case Study on the Use of an Integrated Approach to Testing and Assessment for Identifying Estrogen Receptor Active Chemicals (OECD IATA Webinar) (PRESENTATION)
The Integrated Approach to Testing and Assessment (IATA) has been clarified further to demonstrate that a subset of as few as 4 assays is recommended as an alternative approach to the current guideline. The subset of assays can be any assays that fit into specific criteria as de...
20190331 - CompTox Chemicals Dashboard: Data and Tools to Support Chemical and Environmental Risk Assessment and the ENTACT project (ACS Spring 2019) (PRESENTATION)
Information and data on chemicals is used by scientists to evaluate potential health and ecological risks due to environmental exposures. EPA’s CompTox Chemicals Dashboard (https://comptox.epa.gov) helps evaluate the safety of chemicals by providing public access to a varie...
20190331 - EPA CompTox Chemicals Dashboard: An Online Resource for Environmental Chemists (ACS Spring 2019) (PRESENTATION)
The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This involves computational and data-driven app...
20190313 - Evidence Based Toxicokinetics (SOT CTSS 2019) (PRESENTATION)
Toxicokinetics (TK) describes the Absorption, Distribution, Metabolism, and Excretion (ADME) of a chemical by the body. TK relates external exposures to internal tissue concentrations of chemical. Most industrial chemicals, ranging from industrial waste to dyes to packing materia...
20190331 - Antony Williams, the ChemConnector: A career path through a diverse series of roles and responsibilities (ACS Spring 2019) (PRESENTATION)
Antony Williams is a Computational Chemist at the US Environmental Protection Agency in the National Center for Computational Toxicology. He has been involved in cheminformatics and the dissemination of chemical information for over thirty years. He has worked at a university as ...
20190331 - Developing an Integrated Model Management Solution to Assure Quality of Predicted Data at the US EPA’s National Center of Computational Toxicology (ACS Spring 2019) (PRESENTATION)
The Computational Toxicology Program within the U.S. Environmental Protection Agency (EPA) integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human and environmental health risks. A key component of...
20190331 - The True Positives in EPA's Non-Targeted Analysis Collaborative Trial (ENTACT) (ACS Spring 2019) (PRESENTATION)
For over 13 years, the US EPA’s National Center for Computational Toxicology (NCCT) has been collecting and organizing data relevant to evaluating the risk associated with chemical substances. These efforts have resulted in the development of databases covering publicly ava...
20190331 - Mapping of chemical identifiers to DSSTox to enable data integration in the US-EPA CompTox Chemicals Dashboard (ACS Spring 2019) (PRESENTATION)
The Computational Toxicology Program within the U.S. Environmental Protection Agency (EPA) integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human and environmental health risks. A key component o...
20190331 - US-EPA CompTox Chemicals Dashboard - a Web-based Data Integration Hub for Environmental Chemistry Data (ACS Spring 2019) (PRESENTATION)
The National Center for Computational Toxicology (NCCT) at the US Environmental Protection Agency has measured, assembled and delivered to the community an enormous quantity and diversity of data for the environmental sciences, including high-throughput in vitro screening data, i...
20190331 - Consensus Ranking and Fragmentation Prediction for Identification of Unknowns in High Resolution Mass Spectrometry (ACS Spring 2019) (PRESENTATION)
High resolution mass spectrometry (HRMS) and non-targeted analysis (NTA) have advanced structure identification of unknowns in various sources including environmental media and food stuffs. Structure identification requires the integration of complementary data types such as ref...
20190331 - Applications of a Chemotype-Enrichment Approach to the ToxCast Data Landscape and Beyond: Inverting the SAR Paradigm - ACS Spring 2019 (PRESENTATION)
Traditional structure-activity relationship (SAR) approaches to modeling in toxicology are bounded and determined by the chemicals in the tested space, and are limited by such factors as size and structure diversity of that tested space, mechanistic diversity of the activity endp...
20190328 - CompTox Chemicals Dashboard v3 and invitroDB v3.1 (CompTox CofP) (PRESENTATION)
This talk will give an overview of changes made since the August 2018 release with new data enhancements and new user interface elements. We will also cover work in progress and future plans for features and functionality.
20190424 - Computational Approaches to Developmental and Reproductive Toxicology (UNC Tox Lecture) (PRESENTATION)
New approach methods (NAMs) are available for high-throughput screening (HTS) chemical inventories for profiling chemical-biological interactions in vitro. Adverse outcome pathways (AOPs) provide a framework for quantitative prediction of cellular and tissue responses to molecula...