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Wildland fires are increasingly linked to adverse health impacts related to poor air quality. For instance, short-term exposure to smoldering peat (SP) air pollution in eastern North Carolina during separate burns in 2008 and 2011 led to increased cardiopulmonary emergency room v...

Apelin has cardiopulmonary protective properties that promote vasodilation and maintenance of the endothelial barrier. While reductions in apelin have been identified as a contributor to various lung diseases, including pulmonary edema, its role in the effect of air pollutants ha...

The multivariate AMBI (M-AMBI) is an extension of the AZTI Marine Biotic Index (AMBI) that has been used extensively in Europe, but not in the United States. In a previous study, we adapted AMBI for use in US coastal waters (US AMBI), but saw biases in salinity and score distribu...

Natural disasters often impose significant and long-lasting stress on financial, social and ecological systems. From Atlantic hurricanes to Midwest tornadoes to Western wildfires, no corner of the U.S. is immune to the threat of devastating climate events. Across the nation, ther...

In estuaries, land-surface and tidal elevation conspire to influence the amount of salt-water inundation in a specific location, ultimately affecting the distribution of estuary vegetation. Plants vary in their tolerances to salinity and inundation. Understanding even small chang...

Atmospheric models that accurately describe the fate and transport of trace species for the right reasons aid in the development of effective air-quality management strategies that safeguard human health. Controllable emissions facilitate the formation of biogenic secondary organ...

There is increasing evidence that diverse xenobiotic metabolizing enzymes exist among fishes, potentially resulting in different chemical sensitivities and accumulation, but this has never been systematically evaluated. One concern is that model test species such as rainbow trou...

Recent studies showed that the circulating stress hormones, epinephrine and corticosterone/cortisol, are involved in mediating ozone-induced pulmonary effects through the activation of the sympathetic-adrenal-medullary (SAM) and hypothalamus-pituitary-adrenal (HPA) axes. Hence, w...

Heart disease is increasing globally with a significant percentage of the increase being attributed to chemical and pollution exposures. Currently, no alternative or in vitro testing models exist to rapidly and accurately determine the cardiac effects of chemicals and/or pollutan...

This research paper uses case analysis methods to understand why participants engage in this innovative approach public participation in scientific research, and what they hope that will mean for their community. The research questions that guide this analysis are: 1) what factor...

In 2007, the U.S. National Research Council laid out a vision and strategy for toxicity testing in the 21st century, which aspired to transform current testing approaches by making greater use of recent scientific advances in cell-based and computational methods. The adverse outc...

Nanotechnology has significant economic, health, and environmental benefits, including renewable energy and innovative environmental solutions. Manufactured nanoparticles have been incorporated into new materials and products because of their novel or enhanced properties. These v...

This work presents the results of an international interlaboratory comparison on ex situ passive sampling in sediments. The main objectives were to map the state of the science in passively sampling sediments, identify sources of variability, provide recommendations and practica...

In 2016, an international multi-sector steering committee focusing on the development of a Society of Environmental Toxicology &amp;amp; Chemistry (SETAC) Pellston&trade; Workshop reached out to the membership of the Society of Toxicology, as well as other national and internatio...

The Adverse Outcome Pathway (AOP) framework has emerged to capitalise on the vast quantity of mechanistic data generated by alternative techniques (such as in vitro and in chemico), as well as advances in systems biology, cheminformatics, and bioinformatics. AOPs provide a scaffo...

Due to the ever-increasing number of chemicals coming to market, and the cost of performing traditional in vivo studies, there has been a shift towards the use of less costly alternative techniques. The adverse outcome pathway (AOP) concept has emerged as a scaffold for organisin...

In 2016, an international multi-sector steering committee focusing on the development of a Society of Environmental Toxicology (SETAC) Pellston Workshop reached out to the membership of the Society of Toxicology as well as other national and international scientific and regulator...

This presentation highlights our &quot;supermix&quot; study which included 15 different environmental anti-androgens (6 pesticides and 9 phthalates) with a dosing structure based on the individual chemical NOAELs. Exposures were conducted in utero (dam oral gavage) during the ma...

The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental biological processes...

The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental biological processes...

The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental biological processes...

Chemicals induce liver cancer in rodents through well characterized adverse outcome pathways (AOPs). We hypothesized that measurement of molecular initiating events (MIEs) and downstream key events (KEs) in liver cancer AOPs in short-term assays will allow early identification of...

Citizen science provides quantitative results to support environmental health assessments, but standardized approaches do not currently exist to translate findings into actionable solutions. The emergence of low-cost portable sensor technologies and proliferation of publicly avai...

Over time, risk assessment has shifted from establishing relationships between exposure to a single chemical and a resulting adverse health outcome, to evaluating multiple chemicals and disease outcomes simultaneously. As a result, there is an increasing need to better understand...

Epoxy-based materials are widely used for coatings, electronics insulations, and waterproofing applications due to their excellent properties such as excellent adhesion, electrical insulation, and heat resistance along with the strong mechanical property. The making of composites...