Science Inventory

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Leonard, J., R. Goldsmith, D. Chang, AND Yumei Tan. A workflow to investigate exposure and pharmacokinetic influences on high-throughput in vitro chemical screening based on adverse outcome pathways, OpenTox USA 2015 Poster. OpenTox USA 2015, Baltimore, MD, February 10 - 12, 2015.

Edwards, S., N. Oki, S. Bell, M. Nelms, AND C. Tan. Accelerating Adverse Outcome Pathway Development via Systems Approaches. SETAC North America 36th Annual Meeting, Salt Lake City, UT, November 01 - 05, 2015.

Tan, C., M. Phillips, H. El-Masri, AND S. Edwards. An “ADME Module” in the Adverse Outcome Pathway Knowledgebase. Society of Toxicology 2015 Annual Meeting, San Diego, CA, March 23 - 27, 2015.

Phillips, M., M. Yoon, B. Young, AND C. Tan. Biomarker Utility Analysis Using an Exposure-PBPK/PD Model: A Carbaryl Case Study. 2015 Annual Meeting of the Society of Toxicology, San Diego, CA, March 22 - 26, 2015.

Tan, C. Biomarkers in risk assessment: use, challenges, and lessons learned. Biomarkers of Tobacco Exposure: A Public Workshop. FDA, Silver Spring, MD, Silver Spring, MD, August 03 - 04, 2015.

Edwards, S., N. Oki, S. Bell, M. Nelms, AND C. Tan. Computationally-Predicted AOPs and Systems Toxicology. 20th North American ISSX Meeting, Orlando, FL, October 18 - 22, 2015.

Lu, J., M. Goldsmith, Chris Grulke, J. Leonard, E. Hypes, M. Fair, R. Tornero-Velez, AND C. Tan. Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction - poster. ASCCT Annual Meeting, EPA RTP Campus, Durham (RTP), NC, October 01 - 02, 2015.

Price, P. AND C. Tan. Exposure Assessments and Toxicology in the 21st Century. Future Tox III, Arlington, VA, November 19 - 20, 2015.

Edwards, S., N. Oki, S. Bell, M. Nelms, J. Leonard, AND C. Tan. Merging Adverse Outcome Pathway (AOP) and Mode of Action (MOA) Frameworks: Assembling Knowledge for Use in Risk Assessment. SRA 2015 Annual Meeting, Arlington, VA, December 06 - 10, 2015.

Tan, C. Pieces of the Puzzle: Tracking the Chemical Component of the Exposome. Exposome workshop, Leipzig, GERMANY, December 14 - 15, 2015.

Brown, K., M. Phillips, C. Grulke, M. Yoon, B. Young, R. McDougall, J. Leonard, J. Lu, W. Lefew, AND C. Tan. Reconstructing Exposures from Biomarkers using Exposure-Pharmacokinetic Modeling - A Case Study with Carbaryl. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 73(3):689-698, (2015).

Sobus, J., K. Christensen, M. Phillips, T. Blessinger, M. Lorber, AND C. Tan. Spot Sampling and Exposure Surrogate Selection as Sources of Bias in Environmental Epidemiology Studies. ISES Annual Meeting, Henderson, NV, Henderson, NV, October 18 - 23, 2015.

Tan, C. Tools in Support of PK and ADME Profiling. LRSS Workshop, Brussels, BELGIUM, September 21 - 22, 2015.

Sobus, J., Rob Dewoskin, C. Tan, J. Pleil, M. Philips, BJ George, K. Christensen, D. Schreinemachers, M. Williams, E. Hubal, AND S. Edwards. Uses of NHANES biomarker data for chemical risk assessment: Trends, challenges and opportunities. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 123(10):919-927, (2015).

Phillips, M., J. Sobus, Barbara J. George, K. Isaacs, R. Conolly, AND C. Tan. A New Method for Generating Distribution of Biomonitoring Equivalents to Support Exposure Assessment and Prioritization. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 69(3):434-442, (2014).

LaKind, J., J. Sobus, M. Goodman, D. Barr, P. Furst, R. Albertini, T. Arbuckle, G. Schoeters, C. Tan, J. Teeguarden, R. Tornero-Velez, AND C. Weisel. A Proposal for Assessing Study Quality: Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals (BEES-C) Instrument. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, 73(2014):195-207, (2014).

Phillips, M., M. Yoon, B. Young, AND C. Tan. Analysis of Biomarker Utility using a PBPK Model for Carbaryl. Frontiers in Pharmacology. Frontiers, Lausanne, Switzerland, 5(246):1-10, (2014).

Tan, C., D. Chang, M. Phillips, S. Edwards, Chris Grulke, Rocky Goldsmith, J. Sobus, R. Conolly, R. Tornero-Velez, AND C. Dary. Biomarkers in Computational Toxicology. Chapter 63, Biomarkers in Toxicology. Elsevier, Shannon, Ireland, , 1039-1055, (2014).

Goldsmith, Rocky, Chris Grulke, R. Brooks, T. Transue, C. Tan, A. Frame, P. Egeghy, R. Edwards, D. Chang, R. Tornero-Velez, K. Isaacs, A. Wang, J. Johnson, K. Holm, M. Reich, J. Mitchell, D. Vallero, L. Phillips, M. Phillips, J. Wambaugh, R. Judson, T. Buckley, AND C. Dary. Development of a Consumer Product Ingredient Database for Chemical ExposureScreening and Prioritization. FOOD AND CHEMICAL TOXICOLOGY. Elsevier Science Ltd, New York, NY, 65:269-279, (2014).

Yin, Y., D. Chang, C. Grulke, C. Tan, M. Goldsmith, AND R. Tornero-Velez. Essential Set of Molecular Descriptors for ADME Prediction in Drug and Environmental Chemical Space. Research. Synatom Research, Lambertville, NJ, (1):996, (2014).

Lee, S., C. Tan, J. Sobus, M. Phillips, AND S. Kim. Estimation of methylmercury intake doses in the South Korea population using a PBPK model. Presented at Society of Toxicology, Phoenix, AZ, March 23 - 27, 2014.

Goldsmith, M., D. Vallero, P. Egeghy, D. Chang, Chris Grulke, C. Tan, AND J. Wambaugh. Ex Priori: Exposure-based Prioritization across Chemical Space. Presented at ISES 2014, Cincinnati, OH, October 12 - 16, 2014.

Breen, M., T. Long, Brad Schultz, J. Crooks, M. Breen, J. Langstaff, K. Isaacs, C. Tan, R. Williams, Y. Cao, A. Geller, R. Devlin, S. Batterman, AND T. Buckley. GPS-based Microenvironment Tracker (MicroTrac) Model to Estimate Time-Location of Individuals for Air Pollution Exposure Assessments: Model Evaluation in Central North Carolina. ATMOSPHERIC ENVIRONMENT. Elsevier Science Ltd, New York, NY, 24(4):412-420, (2014).

Holm, K., Rocky Goldsmith, D. Chang, Chris Grulke, M. Phillips, C. Tan, AND R. Tornero-Velez. Identification and Prioritization of Chemical Mixtures from Environmental Residue Data. Presented at SOT Annual Meeting, Phoenix, AZ, March 23 - 27, 2014.

Sobus, J., J. LaKind, M. Goodman, D. Barr, P. Furst, R. Albertini, T. Arbuckle, G. Schoeters, C. Tan, J. Teeguarden, R. Tornero-Velez, AND C. Weisel. The Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals (BEES-C) Instrument for Assessing Study Quality. ISES 2014 Conference, Cincinnati, OH, October 12 - 16, 2014.