Science Inventory

Saili, K., T. Zurlinden, A. Schwab, A. Silvin, N. Baker, S. Hunter, F. Ginhoux, AND T. Knudsen. Blood-Brain Barrier Development: Systems Modeling and Predictive Toxicology. Birth Defects Research, Part C: Embryo Today: Reviews. John Wiley & Sons, Ltd., Indianapolis, IN, 109(20):1680-1710, (2017). https://doi.org/10.1002/bdr2.1180

Theunissen, P., S. Beken, B. Beyer, W. Breslin, G. Cappon, C. Chen, G. Chmielewski, L. De Schaepdrijver, B. Enright, J. Foreman, W. Harrouk, K. Hew, A. Hoberman, J. Hui, TB Knudsen, S. Laffan, S Makris, AND M Martin. Comparing rat and rabbit embryo-fetal developmental toxicity studies for 379 pharmaceuticals: On systemic dose and developmental effects (Critical Reviews in Toxicology) . CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, , 1-13, (2016).

Theunissen, P., S. Beken, B. Beyer, W. Breslin, G. Cappon, C. Chen, G. Chmielewski, L. De Schaepdrijver, B. Enright, J. Foreman, W. Harrouk, K. Hew, A. Hoberman, J. Hui, TB Knudsen, S. Laffan, S Makris, M Martin, M. McNerney, C. Siezen, D. Stanislaus, J. Stewart, K. Thompson, B. Tornesi, G. Weinbauer, S. Wood, J. Van der Laan, AND A. Piersma. Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects (Critical Reviews in Toxicology) . CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, , 1-11, (2016).

Leung, Maxwell C.K., S. Hutson, A. Seifert, R. Spencer, AND T. Knudsen. Computational Modeling and Simulation of Genital Tubercle Development. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, , 1-11, (2016).

Leung, M., J. Phuong, N. Baker, N. Sipes, G. Klinefelter, M. Martin, K. McLaurin, Woodrow Setzer, S. Darney, R. Judson, AND T. Knudsen. Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 124(7):1050-1061, (2016).

Leist, M., N. Hasiwa, C. Rovida, M. Daneshian, D. Basketter, I. Kimber, H. Clewell, T. Gocht, A. Goldberg, F. Busquet, A. Rossi, M. Schwarz, M. Stephens, R. Taalman, T. Knudsen, J. McKim, G. Harris, D. Pamies, AND T. Hartung. Consensus report on the future of animal-free systemic toxicity testing. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 31(3):341-356, (2014).

BASKETTER, D. A., H. J. CLEWELL, I. KIMBER, A. ROSSI, B. BLAAUBOER, R. BURRIER, M. DANESHIAN, C. ESKES, A. GOLDBERG, N. HASIWA, S. HOFFMANN, J. JAWORSKA, T. B. KNUDSEN, R. LANDSIEDEL, M. LEIST, P. LOCKE, G. MAXWELL, J. MCKIM, E. A. MCVEY, G. OUEDRAOGO, G. PATLEWICZ, O. PELKONEN, E. ROGGEN, C. ROVIDA, I. RUHDEL, M. SCHWARZ, A. SCHEPKY, G. SCHOETERS, N. SKINNER, K. TRENTZ, M. TURNER, P. VANPARYS, J. YAGER, J. ZURLO, AND T. HARTUNG. A Roadmap for the Development of Alternative (Non-Animal) Methods for Systemic Toxicity Testing. SONJA von AULOCK, Editor in chief (ed.), ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 1(29):1-91, (2012).

KNUDSEN, T. B. AND N. C. KLEINSTREUER. Disruption of Embryonic Vascular Development in Predictive Toxicology. Anthony M. DeLise (Guest Editor) (ed.), Birth Defects Research, Part C: Embryo Today: Reviews. John Wiley & Sons, Ltd., Indianapolis, IN, 93(4):312-323, (2011).

MARTIN, M. T., T. B. KNUDSEN, R. JUDSON, R. J. KAVLOCK, AND D. J. DIX. Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program . Stephen A. Krawetz (Editor-in-Chief) (ed.), Systems Biology in Reproductive Medicine. Informa Healthcare USA, New York, NY, 58(1):3-9, (2012).

KLEINSTREUER, N., D. J. DIX, K. A. HOUCK, R. J. KAVLOCK, T. B. KNUDSEN, M. T. MARTIN, K. B. PAUL, D. REIF, K. M. CROFTON, K. HAMILTON, R. HUNTER, I. A. SHAH, AND R. JUDSON. In vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, Epub(Advance Access):1-44, (2012).

PADILLA, S. J., D. CORUM, B. K. PADNOS, D. L. HUNTER, A. BEAM, K. A. HOUCK, N. SIPES, N. KLEINSTREUER, T. B. KNUDSEN, D. J. DIX, AND D. M. REIF. Zebrafish Developmental Screening of the ToxCast™ Phase I Chemical Library . REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 33(2):174-187, (2012).

KNUDSEN, T. B., K. A. HOUCK, N. SIPES, A. V. SINGH, R. JUDSON, M. T. MARTIN, A. WEISSMAN, N. KLEINSTREUER, H. M. MORTENSEN, D. REIF, J. R. RABINOWITZ, R. W. SETZER, A. M. RICHARD, D. J. DIX, AND R. J. KAVLOCK. Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. TOXICOLOGY. Elsevier Ireland Limited, Limerick, Ireland, 282(1-2):1-15, (2011).

KNUDSEN, T. B., R. J. KAVLOCK, G. P. DASTON, D. B. STEDMAN, M. HIXON, AND J. KIM. Developmental toxicity testing for safety assessment: new approaches and technologies. BIRTH DEFECTS RESEARCH PART B: DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY. John Wiley & Sons, Inc, Hoboken, NJ, 92(5):413-420, (2011).

GREEN, M. L., A. V. SINGH, L. RUEST, MICHELE M. PISANO, R. A. PROUGH, AND T. B. KNUDSEN. Differential programming of p53-deficient embryonic cells during rotenone block. TOXICOLOGY. Elsevier Ireland Limited, Limerick, Ireland, 290(1):31-41, (2011).

KLEINSTREUER, N. C., R. S. JUDSON, D. M. REIF, N. S. SIPES, A. V. SINGH, K. J. CHANDLER, R. DEWOSKIN, D. J. DIX, R. J. KAVLOCK, AND T. B. KNUDSEN. Environmental Impact on Vascular Development Predicted by High Throughput Screening. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 119(11):1596-1603, (2011).

KLEINSTREUER, N. C., A. M. SMITH, P. R. WEST, K. CONARD, B. FONTAINE, A. M. WEIR-HAUPTMAN, J. PALMER, T. B. KNUDSEN, D. J. DIX, E. L. DONLEY, AND G. G. CEZAR. Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics . TOXICOLOGY AND APPLIED PHARMACOLOGY. Elsevier Science Inc., Burlington, MA, Online:1-10, (2011).

MARTIN, M. T., T. B. KNUDSEN, D. REIF, K. A. HOUCK, R. JUDSON, R. J. KAVLOCK, AND D. J. DIX. Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening. BIOLOGY OF REPRODUCTION. Society for the Study of Reproduction, 85(2):327-339, (2011).

SIPES, N. S., M. T. MARTIN, D. M. REIF, N. C. KLEINSTREUER, R. S. JUDSON, A. V. SINGH, K. J. CHANDLER, D. J. DIX, R. J. KAVLOCK, AND T. B. KNUDSEN. Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 124(1):109-127, (2011).

SIPES, N. S., S. J. PADILLA, AND T. B. KNUDSEN. Zebrafish – As an Integrative Model for Twenty-first Century Toxicity Testing. Birth Defects Research, Part C: Embryo Today: Reviews. Wiley Liss, New York, NY, 93(3):256-267, (2011).

KAVLOCK, R. J. AND D. J. DIX. Computational Toxicology as Implemented by the U.S. EPA: Providing High Throughput Decision Support Tools for Screening and Assessing Chemical Exposure, Hazard and Risk. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART B: CRITICAL REVIEWS. Taylor & Francis, Inc., Philadelphia, PA, 1(2-4):197-217, (2010).

Ema, M., R. Ise, H. Kato, S. Oneda, A. Hirose, M. Hirata-Koizumi, A. V. SINGH, T. B. KNUDSEN, AND T. Ihara. Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 29(1):49-56, (2010).

KNUDSEN, T. B. AND D. M. KOCHHAR. The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis. Birth Defects Research, Part C: Embryo Today: Reviews. John Wiley & Sons, Ltd., Indianapolis, IN, 90(2):155-162, (2010).

SHAH, I. A. AND J. F. WAMBAUGH. Virtual Tissues in Toxicology. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART B: CRITICAL REVIEWS. Taylor & Francis, Inc., Philadelphia, PA, 13(2-4):314-328, (2010).

KNUDSEN, T. B., M. T. MARTIN, R. J. KAVLOCK, R. JUDSON, D. J. DIX, AND A. V. SINGH. Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA’s ToxRefDB. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 28(2):209-19, (2009).