Main Title |
Analysis of 2,3,7,8-TCDD Tumor Promotion Activity and Its Relationship to Cancer. |
Author |
Holder, J. W. ;
Menzel, H. M. ;
|
CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Hessische Landesanstalt fuer Umwelt, Wiesbaden (Germany, F.R.). |
Publisher |
Mar 90 |
Year Published |
1990 |
Report Number |
OHEA-C-287 ;EPA/600/D-90/006; |
Stock Number |
PB90-187253 |
Additional Subjects |
Malignant neoplasms ;
Carcinogens ;
Rats ;
Mice ;
Exposure ;
Bioassay ;
Tables(Data) ;
Reprints ;
Tetrachlorodibenzo-p-dioxin ;
Carcinogenicity tests ;
Dose-response relationships
|
Internet Access |
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-187253 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has a high estimated cancer potency in animals which has been reasoned to imply that TCDD might be carcinogenic to man. The animal cancer data show that TCDD can act in a solitary manner causing tumors without the participation of other known factors. However, there exist animal cancer data indicating that TCDD can act as a tumor-promoting compound. The analysis examines which type of carcinogen and which mechanism best characterize TCDD cancer activity. It is suggested that TCDD acts by a hormonal mechanism to cause cancer in a solitary manner, at low doses, in two species, and in a number of different organs, including rare sites. These observations in toto characterize TCDD as a complete carcinogen, which by definition encompasses both initiation and promotion carcinogenic activities. |
Supplementary Notes |
Pub. in Chemosphere v19 p1-6. Presented at the International Conference on Dioxins, August 1988, Umea, Sweden. Prepared in cooperation with Hessische Landesanstalt fuer Umwelt, Wiesbaden (Germany, F.R.). |
NTIS Title Notes |
Symposium paper. |
Title Annotations |
Reprint: Analysis of 2,3,7,8-TCDD Tumor Promotion Activity and Its Relationship to Cancer. |
Category Codes |
57Y; 57E |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/21 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
013024988 |
Origin |
NTIS |
Type |
CAT |