Main Title |
Comparative Toxicity Based on Similar Asymptotic Endpoints (Journal Version). |
Author |
Shirazi, M. A. ;
Lowrie, L. ;
|
CORP Author |
Corvallis Environmental Research Lab., OR. ;Northrop Services, Inc., Corvallis, OR. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/243; |
Stock Number |
PB89-145031 |
Additional Subjects |
Toxicity ;
Industrial wastes ;
Asymptotic series ;
Chemical compounds ;
Water pollution ;
Dose rate ;
Exposure ;
Comparison ;
Assessments ;
Statistical analysis ;
Reprints ;
Water pollution effects(Animals) ;
Dose-response relationships ;
Fathead minnows
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-145031 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Results of the laboratory tests are used in assessing the environmental risk of exposure to industrial chemicals. The combined effects of dose-level exposure and time-duration exposure are tested in the laboratory, but only a single endpoint reflecting the dose-level exposure at the end of the test period is routinely reported and used. At times, this might be sufficient, or the data otherwise inappropriate for calculation of more than a single endpoint. Nevertheless, an approach that makes a more complete use of existing sufficient test information is needed. One method is presented in the paper, the focus of which is the evaluation of an LC50 endpoint at a calculated exposure time. This calculation determines a condition for the toxicity curve to become established along the time axis. The authors refer to this condition of the dose-response curve as an asymptotic state and the LC50 calculated from it as the asymptotic LC50. An analysis of 152 toxicity tests using fathead minnows show that the 96-hr LC50 is 25% more conservative than the asymptotic LC50. The calculation of LC50 under asymptotic conditions better enables comparing toxicities of different chemicals on the basis of comparable dose-level and time-duration exposures. (Copyright (c) 1988 Springer-Verlag New York Inc.) |
Supplementary Notes |
Pub. in Archives of Environmental Contamination and Toxicology, v17 p273-280 1988. Prepared in cooperation with Northrop Services, Inc., Corvallis, OR. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Comparative Toxicity Based on Similar Asymptotic Endpoints (Journal Version). |
Category Codes |
68D; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/02 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
908928003 |
Origin |
NTIS |
Type |
CAT |