Main Title |
Stochastic Computer Simulation Methodology for Quantifying the Health Effect of Pollutant Exposure Using Pharmacokinetic Models. |
Author |
Kowal, N. E. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div. |
Year Published |
1988 |
Report Number |
EPA/600/D-88/080; |
Stock Number |
PB88-202486 |
Additional Subjects |
Mathematical models ;
Computerized simulation ;
Drugs ;
Stochastic processes ;
Cadmiums ;
Humans ;
Methods ;
Pharmacokinetic models
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-202486 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
22p |
Abstract |
A stochastic computer simulation methodology for use with continuous dynamic systems is described. The methodology is applied to a pharmacokinetic model of cadmium in humans, and attempts to account for the statistical variability in cadmium exposure through ingestion in quantifying the predicted health effect of cadmium. The methodology consists of four basic steps: formulation of a realistic physiological pharmacokinetic model for humans, derivation of empirical probability distributions for input variables, numerical solution of the model using ordinary differential equation integration methods and random sampling of the input distribution, and, finally, statistical analysis of the output distributions. Several future directions in the development and application of the methodology are described. |
PUB Date Free Form |
Apr 88 |
Category Codes |
57Q#; 72E |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
819623448 |
Origin |
NTIS |
Type |
CAT |