Main Title |
Lung Tumor Induction in Strain a Mice with Benzotrichloride (Journal Version). |
Author |
Stoner, G. D. ;
You, M. ;
Morgan, M. A. ;
Superczynski, M. J. ;
|
CORP Author |
Medical Coll. of Ohio at Toledo. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1986 |
Year Published |
1986 |
Report Number |
EPA/600/J-86/471; |
Stock Number |
PB89-104012 |
Additional Subjects |
Toxic substances ;
Toxicity ;
Carcinogens ;
Occupational safety and health ;
Lung neoplasms ;
Laboratory animals ;
Dose-response relationships ;
Chlorine organic compounds ;
Reprints ;
Benzotrichloride ;
Benzene/trichloromethyl
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-104012 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Benzotrichloride (BTC) is used in the synthesis of benzoyl chloride and benzoyl peroxide. Epidemiological data suggest that BTC is a human lung carcinogen. In the present study, BTC was evaluated for its ability to induce lung adenomas in strain A/J mice. Four groups of 15 male and 15 female A/J mice were injected i.p. with either tricaprylin or BTC in tricaprylin three times a week for 8 weeks. BTC groups received doses totaling 1440 mg/kg, 719 mg/kg or 287 mg/kg. The mean number of lung tumors per mouse was 127 87 plus or minus 5.81, 43 plus or minus 2.44, and 17.73 plus or minus 1.09 in the groups treated with either 1440 mg/kg, 719 mg/kg, or 287 mg/kg, respectively. Tricaprylin-vehicle controls had a mean number of 0.46 plus or minus 0.15 lung tumors per mouse. Therefore, BTC produced a significant (P<0.001) and dose-related increase in the lung tumor response when compared to tricaprylin controls and is a potent carcinogen in the strain A mouse lung tumor bioassay. (Copyright (c) 1986 Elsevier Scientific Publishers Ireland Ltd.) |
Supplementary Notes |
Pub. in Cancer Letters, v33 p167-173 1986. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Lung Tumor Induction in Strain a Mice with Benzotrichloride (Journal Version). |
Category Codes |
57Y; 57U; 44G; 68G |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
833026585 |
Origin |
NTIS |
Type |
CAT |