Main Title |
Effects of Prenatal Dexamethasone or Terbutaline Exposure on Development of Neural and Intrinsic Control of Heart Rate. |
Author |
Hou, Q. C. ;
Slotkin, T. A. ;
|
CORP Author |
Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA-R-813769; EPA/600/J-89/376; |
Stock Number |
PB90-216235 |
Additional Subjects |
Heart rate ;
Parasympathetic nervous system ;
Sympathetic nervous system ;
Graphs(Charts) ;
Body weight ;
Reprints ;
Prenatal exposure delayed effects ;
Terbutaline ;
Dexamethasone ;
Adrenergic beta receptor blockaders
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-216235 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
The study compares the effects of prenatal exposure to terbutaline (a beta-adrenergic agonist) and dexamethansone (a glucocorticoid) on the development of heart rate control mechanisms in the rat. Both drugs produced a persistent reduction in resting heart rate appearing during the 2nd postnatal wk, but by different mechanisms. Terbutaline affected the development of autonomic input from the CNS, characterized by a premature shift from sympathetic to parasympathetic dominance; thus, heart rate differences between terbutaline-exposed animals and controls resolved with acute treatment with a ganglionic blocking agent (chlorisondamine). Dexamethasone did not alter neural input to the myocardium (its actions were not reversed by ganglionic blockade), but instead reduced the intrinsic heart rate; the prenatal glucocorticoid treatment also reduced the sensitivity of the mydocardium to beta-adrenergic stimulation, a factor that could contribute to the alterations in intrinsic rate. (Copyright (c) 1989 International Pediatric Research Foundation, Inc.) |
Supplementary Notes |
Pub. in International Pediatric Research Foundation, Inc., v26 n6 p554-557 Dec 89. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Prenatal Dexamethasone or Terbutaline Exposure on Development of Neural and Intrinsic Control of Heart Rate. |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
018016184 |
Origin |
NTIS |
Type |
CAT |