| Main Title |
Teratologic Evaluation of Inhaled Methyl Ethyl Ketone in Rats, prepared by Dow Chemical Company with Cover Letter. |
| CORP Author |
Texaco, Inc., Beacon, NY.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
1 Dec 1982 |
| Year Published |
1982 |
| Report Number |
OTS-878210652; |
| Stock Number |
OTS-0206178 |
| Additional Subjects |
Methyl ethyl ketone ;
Toxicology ;
Evaluation ;
Toxicity ;
Solvents ;
Rats ;
Pregnancy ;
Inhalation ;
Gestation ;
Water consumption ;
Incidence ;
Exposure ;
Laboratory tests ;
Dow Chemical Company
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0206178 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
43p |
| Abstract |
Pregnant Sprague-Dawley rats were exposed to 0, 400, 1000 or 3,000 ppm methyl ethyl ketone (MEK) on day 6 through 15 of gestation. Maternal toxicity, as evidenced by decreased weight gain and increased water consumption, was observed among rats exposed to 3,000 ppm MEK. Slight fetotoxicity was observed as evidenced by an increased incidence of some minor skeletal variants among litters from animals exposed to 3,000 ppm MEK. No embryotoxic effects were observed. Although a slight fetotoxic effect and slight maternal toxicity were observed at the highest exposure level, MEK was not embryo-toxic or teratogenic in rats at exposure levels up to 3,000 ppm. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57Y; 57O |
| NTIS Prices |
PC A04/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
009400790 |
| Origin |
NTIS |
| Type |
CAT |
