Main Title |
Aldehyde Dehydrogenase as a Marker for Chemically Initiated Mouse Liver Tumors. |
Author |
Richmond, R. E. ;
Pereira, M. A. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northern Kentucky Univ., Highland Heights. |
Year Published |
1986 |
Report Number |
EPA/600/J-86/343; |
Stock Number |
PB87-180675 |
Additional Subjects |
Aldehydes ;
Dehydrogenation ;
Liver neoplasms ;
Markers ;
Benzaldehydes ;
Nitroso compounds ;
Carcinogens ;
Phenobarbitol ;
Mice ;
Laboratory animals ;
Potable water ;
Reprints ;
DENA(Diethylnitrosamine)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-180675 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The induction of an aldehyde dehydrogenase isozyme (B-ALDH), which uses aromatic aldehydes such as benzaldehyde as substrate and NADP as a cofactor was examined in normal liver and tumors of B6C3F1 male mice. The tumors were induced by either 15 or 45 ppm diethylnitrosamine (DENA) in the drinking water for 4 weeks. In some cases, the DENA treatment was followed with 500 ppm phenobarbital (PB) in the drinking water. DENA increased the percent of the mice that showed B-ALDH activity in their livers 14 weeks after termination of DENA treatment. The B-ALDH activity was confined mainly in the centrilobular region. Fifty weeks after the termination of the DENA treatment the percent of animals with B-ALDH in their livers was not different from control mice. However, a larger number of the tumors exhibited B-ALDH activity. These studies show that B-ALDH is a good histochemical marker for mouse liver tumors and may be useful as a marker for the effect of chemical carcinogens in this species. (Copyright (c) 1986 Elsevier Scientific Publishers Ireland Ltd.) |
Supplementary Notes |
Pub. in Cancer Letters, v31 n2 p205-211 May 86. Prepared in cooperation with Northern Kentucky Univ., Highland Heights. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Aldehyde Dehydrogenase as a Marker for Chemically Initiated Mouse Liver Tumors. |
PUB Date Free Form |
c1986 |
Category Codes |
57Z; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
716922907 |
Origin |
NTIS |
Type |
CAT |