Main Title |
Drinking Water Criteria Document for 1,2-Dichloropropane (Draft). |
CORP Author |
Environmental Protection Agency, Washington, DC. Science Advisory Board. |
Publisher |
9 Mar 88 |
Year Published |
1988 |
Report Number |
SAB/EHC-88/017; |
Stock Number |
PB89-105027 |
Additional Subjects |
Potable water ;
Toxicology ;
Reviews ;
Exposures ;
Chlorine organic compounds ;
Water pollution ;
Public health ;
Laboratory animals ;
Risk ;
Carcinogens ;
Mutagens ;
Drinking water ;
Water quality criteria ;
Dichloropropanes ;
Water pollution effects(Humans) ;
Water pollution effects(Animals) ;
Propane/dichloro ;
Case studies ;
Health risk ;
Occupation safety and health
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-105027 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
After conduct a review of the document, the Halogenated Organics Subcommittee unanimously concluded that the drinking water equivalent level should not be based on the non-carcinogenic endpoints of the National Toxicology Program's 1986 bioassay in male rats. It offered five reasons for this conclusion: (1) the dose of 62 mg/kg bw/day represents a no-observed-effect-level (NOEL) for cancer in male rats; (2) the endpoints of survival, body weight organs and tissues are not sufficiently sensitive; and (3) histological lesions were observed in the testes of some male rats given the 62 mg dose; and (4) to the male reproductive toxin 1,2 dibromo-3-chloropropane are sufficient evidence that the chemical may be a male reproductive toxic; and (5) the NTP bioassay was not designed to supply data for derivation of a drinking water equivalent level. |
Supplementary Notes |
See also PB86-117850. |
NTIS Title Notes |
Final rept. |
Category Codes |
50B; 57Y; 68G; 68D |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
100/00 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834421584 |
Origin |
NTIS |
Type |
CAT |