Main Title |
Percutaneous Absorption of D4 (Octamethylcyclotetrasiloxane). |
CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1994 |
Report Number |
86940001691 |
Stock Number |
OTS0557972 |
Additional Subjects |
Toxicology ;
Health effects ;
Octamethylcyclotetrasiloxane (556-67-2) ;
Pharmaco Kinetics ;
Mammals ;
Humans ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 556-67-2
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0557972 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
104p |
Abstract |
This study evaluated the percutaneous absorption of dimethylcyclosiloxane fluid. Four tissue samples from each of 3 human cadavers was used for these in vitro studies. Five ul doses containing 1.5 uCi radiolabelled dimethylcyclosiloxane fluid were applied to each 1 square centimeter tissue sample. Skin integrity was also evaluated by histopathological examination. Histopathological examination indicated no lesions on the tissue sections. After 24 hours, the total percutaneous absorption (skin compartment and amount absorbed through the skin) was 0.29 percent, 0.47 percent, and 4.4 percent of the applied amount. Greater than 80 percent of the total compound recovered was found in the air traps confirming the relative volatility of this compound. Under conditions of this experiment, the compound was found to volatilize prior to significant absorption. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
1994 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A07/MF A07 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028803790 |
Origin |
NTIS |
Type |
CAT |