Main Title |
Aerosol Therapy Implications of Particle Deposition Patterns in Simulated Human Airways. |
Author |
Martonen, T. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;North Carolina Univ. at Chapel Hill. Dept. of Medicine. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/056; |
Stock Number |
PB91-191635 |
Additional Subjects |
Aerosols ;
Drug administration routes ;
Trachea ;
Bronchi ;
Inhalation ;
Humans ;
Bronchial neoplasms ;
Respiratory system ;
Anatomical models ;
Reprints ;
Particle deposition
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-191635 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
The efficacy of inhalation therapy may be improved by the selective deposition of aerosolized medicines, by explicitly targeting and delivering drugs to prescribed lung sites. Here, the deposition patterns of test aerosols, mapped in surrogate respiratory tracts consisting of replica laryngeal casts and fabricated tracheobronchial models, are analyzed. Particles were preferentially deposited at bifurcations, specifically at carinal ridges. Evidence from other investigations indicates that mucociliary clearance may be impeded at such sites in vivo. When these two effects are coupled, the findings suggest that epithelial cells and receptors at airway branching sites may receive concentrated doses of inhaled pharmacological agents. To focus the effects of airborne drugs the lung should, therefore, be considered as a serial network of Y-shaped bifurcation units. The findings have important implications to aerosol therapy protocols including: (1) the treatment of bronchogenic carcinomas because malignant tumors have a predilection for upper airway bifurcations; and (2) lung diseases related to the afferent nervous system since components of neural pathways frequent such locations. |
Supplementary Notes |
Pub. in Jnl. of Aerosol Medicine, v4 n1 p25-40 Feb 91. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Medicine. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Aerosol Therapy Implications of Particle Deposition Patterns in Simulated Human Airways. |
Category Codes |
57Q; 57S |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
119326372 |
Origin |
NTIS |
Type |
CAT |