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RECORD NUMBER: 317 OF 2621

OLS Field Name OLS Field Data
Main Title Arterial Blood Gases, Pulmonary Function and Pathology in Rats Exposed to 0.75 or 1.0 ppm Ozone.
Author Pepelko, William E. ; Mattox, Joan K. ; Yang, You Yen ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1980
Report Number EPA-600/J-80-179;
Stock Number PB81-148454
Additional Subjects Ozone ; Toxicology ; Rats ; Laboratory animals ; Pathology ; Exposure ; Body weight ; Blood gas analysis ; Respiratory system ; Reprints ; Toxic substances
Holdings
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Status
NTIS  PB81-148454 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 14p
Abstract Arterial blood gases, residual lung volume (RV), deflation pressure volume (PV) curves, pulmonary pathology and body weight changes were studied in rats exposed up to 14 days to either 0.75 or 1.0 ppm ozone. Arterial PO2 and body weights decreased progressively with length of exposure while PaCO2 and RV increased. The slope of the PV curve decreased in all groups exposed to ozone. Pathological changes in the lung increased in severity with concentration and length of exposure. The present findings have shown that arterial blood gas measurements represent a sensitive index of altered lung function in rats, a species very sensitive to ozone exposure.
Supplementary Notes Pub. in Jnl. of Environmental Pathology and Toxicology 3, p247-259 1980.
NTIS Title Notes Journal article.
Title Annotations Reprint: Arterial Blood Gases, Pulmonary Function and Pathology in Rats Exposed to 0.75 or 1.0 ppm Ozone.
PUB Date Free Form 1980
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 323791349
Origin NTIS
Type CAT