Main Title |
In vitro Assessment of Gamete Integrity. |
Author |
Perreault-Darney, S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/D-90/247; |
Stock Number |
PB91-162610 |
Additional Subjects |
Spermatozoa ;
Ovum ;
Fertility ;
Xenobiotics ;
Toxicity ;
In vitro analysis ;
Deoxyribonucleic acids ;
Chromatin ;
DNA damage ;
Aneuploidy ;
Mutation ;
Sperm motility ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-162610 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
16p |
Abstract |
Drugs and xenobiotics can compromise reproductive function by impairing gamete physiology and thereby blocking fertilization, or by damaging gamete DNA or chromatin and thereby causing pregnancy failure or birth defects. Standard measures of gamete integrity, such as morphology, motility (sperm), or fertilizing ability, while useful in identifying and characterizing adverse effects, may not identify genetic damage in the gametes. To better assess gamete integrity, methods capable of detecting DNA or chromosomal damage in individual sperm or egg cells are needed. The report summarizes recent advances in in vitro technologies for assessing both the pathophysiologic and genetic integrity of gametes with emphasis on the latter. |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
113026537 |
Origin |
NTIS |
Type |
CAT |