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OLS Field Name OLS Field Data
Main Title Pyrethroid Insecticides and Radioligand Displacement from the GABA Receptor Chloride Ionophore Complex.
Author Crofton, K. M. ; Reiter, L. W. ; Mailman, R. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Year Published 1987
Report Number EPA/600/J-87/050;
Stock Number PB87-212445
Additional Subjects Insecticides ; Toxicology ; Rats ; Ligands ; Synapses ; Hazardous materials ; Reprints ; Pyrethrins ; Neurotoxins ; Receptors(Gaba-benzodiazepine) ; FLU(Flunitrazepam) ; TBPS(t-butylbicyclophosphorothionate) ; MUS(Muscimol)
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Status
NTIS  PB87-212445 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract Radioligand binding displacement studies were conducted to determine the effects of Type I and II pyrethroids on (3H)-flunitrazepam (FLU), (3H)-muscimol (MUS), and (35S)t-butylbicyclophosphorothionate (TBPS) binding. Competition experiments with (3H)-FLU and (3H)-MUS indicate a lack of competition for binding by the pyrethroids. Type I pyrethroids failed to compete for the binding of (35S)-TBPS at concentrations as high as 50 pM. Type II pyrethroids inhibited (35S)-TBPS binding to rat brain synaptosomes with Ki values ranging from 5-10 pM. The data presented here suggest that the interaction of Type II pyrethroids with the GABA receptor-ionophore complex is restricted to a site near the TBPS/picrotoxinin binding site.
Supplementary Notes Pub. in Toxicology Letters, v35 p183-190 1987. Prepared in cooperation with North Carolina Univ. at Chapel Hill.
NTIS Title Notes Journal article.
Title Annotations Reprint: Pyrethroid Insecticides and Radioligand Displacement from the GABA Receptor Chloride Ionophore Complex.
PUB Date Free Form c1987
Category Codes 57Y; 68E; 68G
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 728119497
Origin NTIS
Type CAT