||Effects of Chronic Topical Application of 12-0-Tetradecanoylphorbol-13-Acetate on the Skin and Internal Organs of SENCAR Mice.
Klein-Szanto, A. J. P. ;
Conti, C. J. ;
Aldaz, C. M. ;
Clapp, N. ;
Nesnow, S. ;
||Texas Univ. System Cancer Center, Houston. ;Oak Ridge National Lab., TN. Biology Div.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Tumor promoters ;
Tetradecanoylphorbol acetate ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Repetitive topical applications of 2 micrograms TPA twice weekly for 37 to 52 weeks induced a sustained epidermal hyperplasia, hyperplasia of hair follicles, and increased dermal cellularity in SENCAR mice. In addition, after 52 weeks of protracted promoter treatment most animals developed generalized amyloidosis involving liver and spleen, as well as interstitial nephritis. Severe pyelonephritis and papillary necrosis were also frequently seen. Reactive lymphoid hyperplasis was also a frequent finding. Chronic administration of TPA is not an inocuous treatment affecting only the interfollicular epidermis. The general effects of the promoter on the animals, probably through impairment of the immune system, decreased markedly their longevity. (Copyright (c) Environmental Health Perspectives Vol. 68, pp. 75-80, 1986.)
||Pub. in Environmental Health Perspectives, v68 p75-80 1986. Prepared in cooperation with Oak Ridge National Lab., TN. Biology Div. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Effects of Chronic Topical Application of 12-0-Tetradecanoylphorbol-13-Acetate on the Skin and Internal Organs of SENCAR Mice.
|PUB Date Free Form
||PC A02/MF A01