| Main Title |
Tumorigenic Effect of Dimethylarsinic Acid in the Rat. |
| Author |
Johansen, M. G. ;
McGowan, J. P. ;
Tu, S. H. ;
Shirachi, D. Y. ;
|
| CORP Author |
University of the Pacific, Stockton, CA.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA-R-807235; EPA/600/D-87/277; |
| Stock Number |
PB88-107271 |
| Additional Subjects |
Arsenic ;
Toxicity ;
Kidney ;
Rats ;
Neoplasms ;
Liver ;
Carcinogens ;
Reprints ;
Tumor promoters ;
Carcinogenesis ;
Arsinic acid/dimethyl
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-107271 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
The development of neoplasms in humans exposed to arsenic in the environment and in industry has been suggested by epidemiological and several recent animal studies. Sodium arsenite (AsIII) has been suggested. As a promoter of tumorigenesis in the kidney of diethylnitrosamine (DENA)-initiated rats. In chronic toxicity studies it was found that dimethylarsinic acid (DMA) was as toxic as the inorganic arsenics, AsIII and AsV (unpubished results). This was an unexpected finding, since it has been assumed from acute toxicity studies that DMA was an inactive metabolite. Since it has been shown by a number of investigators that inorganic arsenics are methylated to DMA, the results of the study with AsIII could have been due to a biotransformed methylated analogue. DMA. A two stage liver model for carcinogenesis was utilized to study the effects of DMA on DENA initiated rats. Data are presented here to suggest that DMA has a promoter carcinogen potential in both the kidney and liver. (Copyright (c) Proc. West. Pharmacol, Soc. 1984.) |
| Supplementary Notes |
Pub. in Proceedings of the Western Pharmacology Society, v27 p289-291 Feb 84. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Tumorigenic Effect of Dimethylarsinic Acid in the Rat. |
| PUB Date Free Form |
c1984 |
| Category Codes |
57Y; 68G; 57O |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
735121345 |
| Origin |
NTIS |
| Type |
CAT |
