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OLS Field Name OLS Field Data
Main Title Maternal Age Effect: The Enigma of Down Syndrome and Other Trisomic Conditions.
Author Gaulden, M. E. ;
CORP Author Texas Univ. Southwestern Medical Center at Dallas. Dept. of Radiology.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/175 ; OHEA-R-478
Stock Number PB93-194421
Additional Subjects Maternal age ; Down syndrome ; Trisomy ; Aneuploidy ; Genetic nondisjunction ; Hormones ; Regional blood flow ; Oxygen ; Carbon dioxide ; Graafian follicle ; Oocytes ; Genetic recombination ; Mutations ; Reprints ; Female genetic risk
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NTIS  PB93-194421 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/23/1993
Collation 22p
Abstract Aneuploidy is the most frequently observed chromosome abnormality in human liveborn, abortuses, and oocytes. The only etiological factor that has been established is advanced maternal age for the occurrence of trisomies, particularly trisomy 21 which causes Down syndrome. The maternal age effect remains an enigma. Recent molecular data bearing on this question are reviewed as are the hypotheses that have been proposed linking nondisjunction and maternal age. Rationale is presented for a compromised microcirculation hypothesis that explains the cause of nondisjunction and why its occurrence changes with maternal age. The hypothesis proposes that aneuploid oocytes arise from a concatenation of events.
Supplementary Notes Pub. in Mutation Research Special Issue, 'Female Germ Cells Biology and Genetic Risk', v296 n1/2 p69-88 Dec 92. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
NTIS Title Notes Journal article.
Title Annotations Reprint: Maternal Age Effect: The Enigma of Down Syndrome and Other Trisomic Conditions.
Category Codes 57E; 57S; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/21
Document Type NT
Cataloging Source NTIS/MT
Control Number 318931947
Origin NTIS
Type CAT