Main Title |
Cytogenetic Analysis of the L5178Y/TK+/- Yields TK-/- Mouse Lymphoma Mutagenesis Assay System. |
Author |
Hozier, J. ;
Sawyer, J. ;
Moore, M. ;
Howard, B. ;
Clive, D. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Florida Inst. of Tech., Melbourne. ;Burroughs-Wellcome Co., Research Triangle Park , NC. |
Year Published |
1981 |
Report Number |
EPA-600/J-81-048; |
Stock Number |
PB84-101732 |
Additional Subjects |
Lymphomas ;
Mice ;
Laboratory animals ;
Assaying ;
Reprints ;
Cytogenetics ;
Mutagenesis
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-101732 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
The L5178Y/TK t/- TK-/- mouse lymphoma mutagen assay, which allows selection of forward mutations at the autosomal thymidine kinase (TK) locus, uses a TK t/- heterozygous cell line, TK t/- 3.7.2C Quantitation of colonies of mutant TK-/- cells in the assay forms the basis for calculations of mutagenic potential of test compounds. The authors have evaluated the banded karyotypes of the parent TK t-/- heterozygous cell line, as well as homozygous TK-/- mutants, in order to relate the genetic and morphological properties of mutant colonies. The parent cell line displays karyotype homogeneity, all cells containing normal mouse chromosomes, readily identifiable chromosome rearrangments, and cell line specific marker chromosomes. |
Supplementary Notes |
Prepared in cooperation with Florida Inst. of Tech., Melbourne and Burroughs-Wellcome Co., Research Triangle Park, NC. |
Availability Notes |
Pub. in Mutation Research 84, p169-181 1981. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Cytogenetic Analysis of the L5178Y/TK+/- Yields TK-/- Mouse Lymphoma Mutagenesis Assay System. |
PUB Date Free Form |
c1981 |
Category Codes |
6T; 6C; 57Y; 57F |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
400621582 |
Origin |
NTIS |
Type |
CAT |