Main Title |
21-day Feeding Study of Di-n-butyl Phthalate to Rats: Effects on the Liver and Liver Lipids. |
CORP Author |
British Industrial Biological Research Association, Carshalton (England).; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1986 |
Report Number |
40-8626209 |
Stock Number |
OTS0509545 |
Additional Subjects |
Toxicology ;
Health effects ;
Phthalate Esters ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Oral ;
Diet ;
Biochemistry ;
Toxic substances ;
Laboratory animals ;
CAS No 84-74-2
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0509545 |
Some EPA libraries have a fiche copy filed under the call number shown. |
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07/26/2022 |
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Collation |
109p |
Abstract |
Effects on the liver and liver lipids were evaluated in groups of male and female Fischer 344 rats (5/sex/dose level) fed nominal levels of 0, 0.6, 1.2 or 2.5% di-n-butyl phthalate in the diet for 21 days. Toxicity was evident by statistical differences between dosed groups and controls for: mean body weights (2.5% and 1.2% group males & 2.5% group females), food consumption (2.5% group males & females), absolute and relative liver weights (all treated animals), relative kidney weights (1.2 and 2.5% group males & 2.5% group females) and absolute and relative testis weights (2.5% group males). There was a statistically significant decrease in serum cholesterol (all treated animals) and a significant decrease in serum triglycerides (all treated males), although these effects were not considered dose-related. Also observed was an significant increase in serum triglycerides for 2.5% group females. There was a moderate increase in peroxisome proliferation for the high dose animals. Liver biochemistry revealed statistically significant differences between treated and controls as indicated by cyanide-insensitive palmitoyl-CoA oxidation levels (1.2 and 2.5% group males & 2.5% group females), lauric acid 11- and 12- hydroxylase activities (all treated males & 2.5% group females) and total hepatic protein levels (0.6 and 1.2% group males, 1.2 and 2.5% group females). There was no consistent dose response relationship among treatment groups for lipid content in the liver. Histological changes attributable to di-n-butyl phthalate were reduction in cytoplasmic basophilia in the livers of the high dose rats and some of the 1.2% group males. Severe testicular atrophy was observed at the 2.5% dietary level. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
1986 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A07/MF A07 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028801330 |
Origin |
NTIS |
Type |
CAT |