| Main Title |
2-year Inhalation Study with N-methyl-2-pyrrolidone in Rats (Final) with Cover Letter Dated 08/30/1990. |
| CORP Author |
; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1990 |
| Report Number |
40-90107123 |
| Stock Number |
OTS0530507 |
| Additional Subjects |
Toxicology ;
Health effects ;
N-methylpyrrolidone ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 872-50-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0530507 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
849p |
| Abstract |
N-methyl-n-pyrrolidinone (CAS No. 872-50-4) was administered to groups of CD rats (15 males/ 15 females) by inhalation at 0.088, 0.423 or 0.74 mg/L for six hours/day for four weeks with 5 treatments/week followed by 14 days of recovery, although due to excessive mortality the high exposure group was taken off treatment after only 10 treatments. All groups showed concentration related increases in lethargy and irregular respiration. The high exposure group showed varying degrees of lymphoid atrophy and necrosis and adverse effects on the hematopoietic tissue, although some of the hematopoietic effects appeared to be reversible during the recovery period. The two lower exposure groups did not exhibit any abnormalities in hematopoietic organs. The high concentration group also showed evidence of testicular atrophy, and an increased neutrophil/lymphocyte ratio which reverted to normal in the recovery period. Organ weight changes which occurred at the different exposures did not have a clear treatment-relationship and no gross or microscopic findings and therefore were not considered biologically significant by the authors. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1990 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A99/MF A99 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803140 |
| Origin |
NTIS |
| Type |
CAT |
