Full Record Display for the EPA National Library Catalog


Main Title 21-day Feeding Study of Di-n-butyl Phthalate to Rats: Effects on the Liver and Liver Lipids.
CORP Author British Industrial Biological Research Association, Carshalton (England).; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 40-8626209
Stock Number OTS0509545
Additional Subjects Toxicology ; Health effects ; Phthalate Esters ; Subchronic Toxicity ; Mammals ; Rats ; Oral ; Diet ; Biochemistry ; Toxic substances ; Laboratory animals ; CAS No 84-74-2
Library Call Number Additional Info Location Last
NTIS  OTS0509545 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 109p
Abstract Effects on the liver and liver lipids were evaluated in groups of male and female Fischer 344 rats (5/sex/dose level) fed nominal levels of 0, 0.6, 1.2 or 2.5% di-n-butyl phthalate in the diet for 21 days. Toxicity was evident by statistical differences between dosed groups and controls for: mean body weights (2.5% and 1.2% group males & 2.5% group females), food consumption (2.5% group males & females), absolute and relative liver weights (all treated animals), relative kidney weights (1.2 and 2.5% group males & 2.5% group females) and absolute and relative testis weights (2.5% group males). There was a statistically significant decrease in serum cholesterol (all treated animals) and a significant decrease in serum triglycerides (all treated males), although these effects were not considered dose-related. Also observed was an significant increase in serum triglycerides for 2.5% group females. There was a moderate increase in peroxisome proliferation for the high dose animals. Liver biochemistry revealed statistically significant differences between treated and controls as indicated by cyanide-insensitive palmitoyl-CoA oxidation levels (1.2 and 2.5% group males & 2.5% group females), lauric acid 11- and 12- hydroxylase activities (all treated males & 2.5% group females) and total hepatic protein levels (0.6 and 1.2% group males, 1.2 and 2.5% group females). There was no consistent dose response relationship among treatment groups for lipid content in the liver. Histological changes attributable to di-n-butyl phthalate were reduction in cytoplasmic basophilia in the livers of the high dose rats and some of the 1.2% group males. Severe testicular atrophy was observed at the 2.5% dietary level.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
PUB Date Free Form 1986
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A07/MF A07
Document Type NT
Cataloging Source NTIS/MT
Control Number 028801330
Origin NTIS
Type CAT