||DDT in the Diet of the Rat: Its Effect on DDT Storage, Liver Function and Cell Morphology.
Ortega, Paul ;
Hayes, Jr., Wayland J. ;
Durham, William F. ;
Mattson., Arnold ;
||Communicable Disease Center, Savannah, Ga.
Laboratory animals ;
Toxic substances ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||A total of 178 male and 104 female white rats were fed levels of DDT ranging from less than 0.05 to 5,000 p.p.m. for periods ranging from 1 week to 14 months. Mortality was not appreciable, and no effect on growth was observed on rats fed levels of 400 p.p.m. or less. Liver weight was definitely increased in rats fed 400 p.p.m; but there was no evidence of increase at 200 p.p.m. or less. Rats stored DDT in proportion to dosage. Both sexes convert a portion of ingested DDT to DDE, but female rats store more DDT and much more DDE than males. Levels of 400 p.p.m. or less produced histological changes in the liver only. The changes in the parenchymal cells of the liver consisted of an increased deposition of fat, margination of cytoplasmic granules, hypertrophy of the cells, and most characteristic--the formation of complex, lipoid, cytoplasmic inclusion bodies termed 'lipospheres.' The authors are in general agreement with Laug and associates in regard to the presence of cellular alterations in the liver of rats fed DDT at levels as low as 5 p.p.m. in the diet.
||Pub. in Public Health Monograph, n43 p1-25 1956. Library of Congress catalog card no. 56-60062.
||Included in the report, Journal Articles on Toxicology, Group 10, PB-280 085.
||Reprint: DDT in the Diet of the Rat: Its Effect on DDT Storage, Liver Function and Cell Morphology,
|PUB Date Free Form
||6T; 57Y; 68G; 68E
||(Order as PB-280 085, MF A01)