Main Title |
Teratology and acute toxicology of selected chemical pesticides administered by inhalation / |
Author |
Newell, Gordon W.
|
Other Authors |
|
Publisher |
U.S. Environmental Protection Agency Health Effects Research Laboratory, |
Year Published |
1978 |
Report Number |
EPA 600/1-78-003; PB 277 077; EPA-68-02-1751 |
Stock Number |
PB-277 077 |
OCLC Number |
20440544 |
Subjects |
Pesticides--Toxicology ;
Teratogenic agents
|
Additional Subjects |
Toxicology ;
Congenital abnormalities ;
Pesticides ;
Insecticides ;
Aerosol generators ;
Aerosols ;
Concentration(Composition) ;
Test chambers ;
Exposure ;
Rats ;
Bioassay ;
Laboratory animals ;
Females ;
Males ;
Lethal dosage ;
Pregnancy ;
Embryology ;
Ingestion(Biology) ;
Cholinesterase ;
Toxicity ;
Pathology ;
Experimental data ;
Teratology ;
Inhalation ;
Fetuses ;
Parathion ;
Intravenous injections ;
Topical administration ;
Azinphosmethyl ;
Phorate
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600-1-78-003 |
|
Headquarters Library/Washington,DC |
05/16/2014 |
EKBD |
EPA-600/1-78-003 |
|
Research Triangle Park Library/RTP, NC |
06/13/2003 |
ELBD ARCHIVE |
EPA 600-1-78-003 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELBD |
EPA 600-1-78-003 |
|
AWBERC Library/Cincinnati,OH |
11/22/2022 |
NTIS |
PB-277 077 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
xii, 49 pages : tables ; 28 cm |
Abstract |
A method was developed for generating pesticide aerosols within the respirable particle size range of 0.3 to 3.0 micrometers. Analytical methods were established for determining pesticide concentrations in chamber air samples and in tissues. A unique chamber exposure system was developed that permitted the simultaneous exposure of four different groups of rats to four different concentrations of pesticide from a single generation source. Parathion, methyl parathion, Thimet, Guthion, and Azodrin were administered to rats by the oral, dermal, intravenous or inhalation routes, and the LD50s or LC50s were compared. Inhalation was the most toxic route of administration, followed by the intravenous, oral, and then dermal routes. Females were more sensitive than males to parathion and Thimet by all routes of administration. Azodrin was more toxic to females by the intravenous and oral routes, and Guthion was more toxic to females by dermal application. No correlation was found between mortality and cholinesterase inhibition or blood or liver pesticide content. No gross or histopathological lesions were identified that could be attributed to pesticide treatment. Timed-pregnant rats were exposed to vapors/aerosols of chloroform, ethylene thiourea, Thimet, Bromacil, and Simazine for 1 to 3 hours daily on days 7 through 14 of gestation. No dose-related terata were found in any of the studies. |
Notes |
"EPA 600/1-78-003." "PB 277 077." "Contract no. 68-02-1751." "January 1978." |
Place Published |
Research Triangle Park, NC |
Access Notes |
Also available via the World Wide Web. |
Corporate Au Added Ent |
Health Effects Research Laboratory (Research Triangle Park, N.C.) ; Health Effects Research Laboratory (Research Triangle Park, N.C.) |
Title Ser Add Ent |
Research reporting series. Environmental health effects research ; EPA-600/78-003. |
PUB Date Free Form |
1978 |
Series Title Untraced |
Research reporting series. 1, Environmental health effects research ; EPA-600/78-003 |
NTIS Prices |
PC A04/MF A01 |
BIB Level |
m |
Medium |
unmediated |
Content |
text |
Carrier |
volume |
Cataloging Source |
OCLC/T |
OCLC Time Stamp |
20221117213018 |
Language |
eng |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
01708cam 2200433 a 45010 |