Main Title |
Postnatal Evaluation of Prenatal Exposure to p -Xylene in the Rat. |
Author |
Rosen, M. B. ;
Crofton, K. M. ;
Chernoff, N. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
Publisher |
c1986 |
Year Published |
1986 |
Report Number |
EPA/600/J-86/489; |
Stock Number |
PB89-104889 |
Additional Subjects |
Toxic substances ;
Xylenes ;
Toxicity ;
Pregnancy ;
Growth ;
Reproduction ;
Exposure ;
Body weight ;
Aromatic hydrocarbons ;
Central nervous system ;
Prenatal exposure delayed effects ;
Laboratory animals ;
Reprints ;
Benzene/p-dimethyl
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-104889 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Pregnant Sprague-Dawley rats were exposed to either 3500 or 7000 mg/m3 p-xylene from days 7-16 of gestation. Dams were allowed to give birth, and litters counted, weighed, and observed for external malformations on postnatal days (PD) 1 and 3. Litters were normalized to 8 pups (4 males and 4 females +1) on PD4. On PD21 animals were weaned and littermates housed by sex. Body weights were recorded weekly until weaning and once every two weeks thereafter. Central nervous system development was evaluated by acoustic startle response on PD13, 17, 21, and 63 as well as figure eight maze activity on PD22 and 65. The data indicate that p-xylene as administered in the study does not appear to be a selective developmental toxicant in the rat. (Copyright (c) Elsevier Science Publishers B.V. (Biomedical Division).) |
Supplementary Notes |
Pub. in Toxicology Letters, v34 p223-229 1986. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Postnatal Evaluation of Prenatal Exposure to p -Xylene in the Rat. |
Category Codes |
57Y; 57H; 44G; 68G |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834421539 |
Origin |
NTIS |
Type |
CAT |