Main Title |
Proconvulsant Activity of Endosulfan in Amygdala Kindling. |
Author |
Gilbert, M. E. ;
|
CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-92/194; |
Stock Number |
PB92-189000 |
Additional Subjects |
Kindling(Neurology) ;
Seizures ;
Endosulfan ;
Amygdala ;
Organochlorine insecticides ;
Toxicology ;
Dose-response relationships ;
GABA ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-189000 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The proconvulsant properties of the chlorinated hydrocarbon insecticide, endosulfan, were investigated using electrical kindling of the amygdala. Male rats were implanted with electrodes in the amygdala and stimulated once daily with a standard kindling stimulus 60-90 min following endosulfan (0, 2.5, 5.0 mg/kg, PO). No alterations were observed in either the threshold to induce an afterdischarge (AD) or the duration of clonus upon seizure generalization. Endosulfan significantly reduced the number of stimulations required to produce Stage 5 generalized seizures. Seizures prior to stimulation were evident in a subset of animals from both dosage groups and were never observed in controls. The presence of kindled seizures was maintained in the absence of further dosing, as amygdala stimulation 2-4 weeks after the last endosulfan treatment resulted in generalized seizures in all animals. The results suggest that faster kindling rates induced by endosulfan are not readily attributable to transient toxicant-related increases in excitability of the nervous system. It was concluded that endosulfan has proconvulsant properties that may be related to an action on GABA within the central nervous system. (Copyright (c) 1992 Pergamon Press Ltd.) |
Supplementary Notes |
Pub. in Jnl. of Neurotoxicology and Teratology, v14 p143-149 1992. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Proconvulsant Activity of Endosulfan in Amygdala Kindling. |
Category Codes |
57Y; 57I; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
220521558 |
Origin |
NTIS |
Type |
CAT |