Main Title |
Effects of Ethylene Chlorohydrin on Fatty Acid Synthesis. |
Author |
Andrews, J. E. ;
Courtney, K. D. ;
Donaldson, W. E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. |
Year Published |
1983 |
Report Number |
EPA-600/J-83-094; |
Stock Number |
PB84-116300 |
Additional Subjects |
Toxicity ;
Food contamination ;
Environmental surveys ;
Fatty acids ;
Fumigation ;
Synthesis(Chemistry) ;
Chickens ;
Dosage ;
Chlorine organic compounds ;
Laboratory animals ;
Reprints ;
Ethanol/chloro
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-116300 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
19p |
Abstract |
Male chicks weighing 700 to 900 g. received an acute or eight doses IG of 60 or 40 mg/kg ethylene chlorohydrin (ECH) respectively and were sacrificed eighteen hours after the last dose. Mitochondrial elongation of fatty acids was decreased significantly while fatty acid synthetase activity was not significantly affected by ECH treatment. Cytochrome c oxidase activity in fresh whole liver homogenate was significantly higher in chicks subjected to acute exposure with ECH when compared to the controls. Upon freezing and thawing of homogenates, cytochrome c oxidase activity increased significantly in the control group but was unchanged in the ECH group which suggests that the mitochondrial membrane integrity is compromised by the ECH treatment. Serum and liver triglyceride levels were significantly elevated in both the single and multiple ECH dose groups. Liver to body weight ratios were significantly higher in both treatment groups when compared to their controls. Histological examination of the liver of ECH-treated chicks showed cytoplasmic clearing of the cells but no vacuolization or centrilobular necrosis. Serum isocitrate dehydrogenase levels were significantly higher in the multiple treatment ECH group than in the control group. (Copyright (c) 1983 by Marcel Dekker, Inc.) |
Supplementary Notes |
Prepared in cooperation with North Carolina State Univ. at Raleigh. |
Availability Notes |
Pub. in Jnl. of Environmental Science and Health B18(3), p351-367 1983. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Ethylene Chlorohydrin on Fatty Acid Synthesis. |
PUB Date Free Form |
c1983 |
Category Codes |
6T; 6A; 57Y; 68; 57B; 99 |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
403420829 |
Origin |
NTIS |
Type |
CAT |