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RECORD NUMBER: 3 OF 309

OLS Field Name OLS Field Data
Main Title 7,12-Dimethylbenz(a)anthracene-Deoxyribonucleoside Adduct Formation 'in vivo': Evidence for the Formation and Binding of a Monohydroxymethyl-DMBA (Dimethylbenz(a)anthracene) Metabolite to Rat Liver DNA (Deoxyribonucleic Acid).
Author Joyce, N. J. ; Daniel, F. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-82-275;
Stock Number PB83-163477
Additional Subjects Carcinogens ; Deoxyribonucleic acids ; Rats ; Liver ; Deoxyribonucleic acids ; Parenteral infusions ; Chemical analysis ; Fluorescence ; Aromatic polycyclic hydrocarbons ; Malignant neoplasms ; Reprints ; Benzanthracene/dimethyl ; Benzanthracene/hydroxymethyl-dimethyl ; High performance liquid chromatography ; Cancer
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB83-163477 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 7p
Abstract The polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA) is a potent carcinogen to the female Sprague-Dawley rat, and when administered under conditions that have been shown to produce cancer, results in extensive formation of hydrocarbon-deoxyribonucleoside adducts. Sephadex LH-20 and reverse-phase h.p.l.c. and spectrofluorometric analysis of these adducts demonstrate that at least one adduct results from the binding of 7,12-dimethylbenz(a)anthracene-1,2,3,4-tetrahydro-3,4-dihydroxy-1,2-oxide.
Supplementary Notes Pub. in Carcinogenesis, v3 n3 p297-301 1982.
NTIS Title Notes Journal article.
Title Annotations Reprint: 7,12-Dimethylbenz(a)anthracene-Deoxyribonucleoside Adduct Formation 'in vivo': Evidence for the Formation and Binding of a Monohydroxymethyl-DMBA (Dimethylbenz(a)anthracene) Metabolite to Rat Liver DNA (Deoxyribonucleic Acid).
PUB Date Free Form 1982
Category Codes 6T; 7D; 57Y; 99A
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 314724386
Origin NTIS
Type CAT