Main Title |
Causes of Papillomas on Fish Living in Chlorinated Sewage Effluent. |
Author |
Grizzle, John M. ;
Melius, Paul ;
|
CORP Author |
Auburn Univ., AL.;Environmental Research Lab., Gulf Breeze, FL. |
Year Published |
1982 |
Report Number |
EPA-CR-807844-010; EPA-600/3-82-087; |
Stock Number |
PB83-111039 |
Additional Subjects |
Chlorination ;
Papilloma ;
Effluents ;
Neoplasms ;
Toxicology ;
Fresh water fishes ;
Alabama ;
Fishes ;
Mutagens ;
Carcinogens ;
Ictalurus melas ;
Ictalurus natalis ;
Ictalurus punctatus ;
Tuskegee(Alabama) ;
Sewage treatment effluents ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB83-111039 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
38p |
Abstract |
This research was initiated to determine the cause of the oral papillomas on black bullheads (Ictalurus melas) from the final oxidation pond of the Tuskegee, Alabama, sewage treatment plant. Ames-test mutagenicity of a pond-water concentrate indicated the presence of a chemical carcinogen in the pond water. However, water and sediment analysis did not identify substances suspected of causing the tumors. Cytoplasmic inclusion bodies were present in some papilloma cells, but attempts to find virions in the tumor using electron microscopy and to transmit the papillomas by injection of cell-free tumor homogenate into black bullheads were not successful. Juvenile black bullheads, yellow bullheads (Ictalurus natalis), and channel catfish (Ictalurus punctatus) were confined to cages in the oxidation pond and in a control pond. Caged fish did not develop neoplasms but most caged black bullheads in the oxidation pond developed focal, oral hyperplasia and stomatitis in the same mouth locations occupied by papillomas in wild black bullheads from this pond. |
NTIS Title Notes |
Final technical rept.. |
PUB Date Free Form |
Oct 82 |
Category Codes |
6T; 6F; 57Y; 68D |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/04 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
830724041 |
Origin |
NTIS |
Type |
CAT |