| Main Title |
Initial Submission: Tetrahydrofuran Teratogenicity - Results of Pilot Study (Part I) with Cover Letter Dated 03/27/1992. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920001525 |
| Stock Number |
OTS0535909 |
| Additional Subjects |
Toxicology ;
Health effects ;
Tetrahydrofuran ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 109-99-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0535909 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
Tetrahydrofuran (CAS No. 109-99-9) was evaluated for developmental toxicity in groups of 14, 7, 6, 7, and 7 pregnant CD rats, exposed to 0, 200, 500, 2500 or 5000 ppm respectively for 6 hours/day from days 6 through 15 of gestation. Dams at 5000 ppm did not respond to a sound stimulus, had poor muscle tone and a staggered gait during exposure. Maternal body weight gain from days 1-21 of gestation in the high dose group was less than controls, but the difference was not statistically significant. At 5000 ppm the mean fetal body weight was significantly less than controls and petechial hemorrhage was significantly different from controls. No evidence of teratogenic potential was demonstrated. Embryotoxicity occurred at 5000 ppm, which was the concentration toxic to dams. No other differences in terms of implants, fetal malformations (external, visceral, skeletal), or variations were reported as significantly different from controls. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803460 |
| Origin |
NTIS |
| Type |
CAT |
