| Main Title |
Initial Submission: Tetrahydrofuran (thf) Inhalation: Effect on the Rat Conceptus (Final Report) with Attachments and Cover Letter Dated 03/27/1992. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920001524 |
| Stock Number |
OTS0535908 |
| Additional Subjects |
Toxicology ;
Health effects ;
Tetrahydrofuran ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 109-99-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0535908 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
112p |
| Abstract |
Tetrahydrofuran (CAS No. 109-99-9) was evaluated for developmental toxicity. In part I of the experiment the test material was administered to 14, 7, 7, 7, and 7 CD rats by inhalation at exposure levels of 0, 200, 500, 2500, and 5000 ppm, respectively on gestational days 6-15. In part II, 29, 87, and 38 CD rats were administered the test material by inhalation at exposure levels of 0, 1000, and 5000 ppm, respectively from days 6-15 of gestation. In both parts I and II, no maternal deaths occurred but the 5000 ppm exposure induced significant decreases in feed consumption (p<0.05) and body weight gain (p<0.05) along with absence of response to noise stimulus during the exposure period, followed by lethargy and incoordination for 1 hour post-exposure. No toxic responses were observed at 200 or 500 ppm (part I). At 1000 ppm (part II) and 2500 ppm (part I) only a reduced response to a noise stimulus was observed in comparison to controls. The mean number of implantations per dam and the incidence of malformed fetuses were not exposure related (among part I or part II). At 5000 ppm, the fetal variations of reduced weight and less ossified sternae were significantly different (p<0.05) from controls (for both part I and part II). Embryotoxicity expressed as developmental delay occurred at 5000 ppm. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803450 |
| Origin |
NTIS |
| Type |
CAT |
