Main Title |
Initial Submission: Basic Toxicity of 4-Methoxy-1-Naphthol with Cover Letter dated 09/08/1992. |
CORP Author |
Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1992 |
Report Number |
8EHQ-0992-10994 |
Stock Number |
OTS0571032 |
Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
4-methoxy-1-naphthol ;
Acute toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Mice ;
Primary dermal irritation ;
Guinea pigs ;
Dermal ;
Primary eye irritation ;
Rabbits ;
Primary dermal sensitization ;
Subchronic toxicity ;
Diet ;
Environmental effects ;
Freshwater fish ;
Invertebrates ;
Mollusks ;
Plants ;
CAS No 84-85-5
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0571032 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
The report pertains to 4-methoxy-1-naphthalenol (synonym: 4-methoxy-1-naphthol) (CAS No. 84-85-5) and is being submitted because of effects observed in a study conducted by multiple exposure routes. The title of the report being submitted is: 'Basic Toxicity of 4-Methoxy- 1-naphthol'. The latter report is being identified as a study involving other than human effects (Unit II.B.2.b of CAP Agreement). Groups of five rats were fed 1.0 % (925 mg/kg/day) or 0.1 % (100 mg/kg/day) of the test compound in the diet for twelve days. Exposure at the high-dose level decreased feed intake and reduced weight gain. Abnormalities in the high-dose group included: a great increase in absolute and relative spleen weights, enlarged spleens, and splenic congestion not associated with any lymphoid or reticuloeodothelial effect- slight decrease in hemoglobin and hematocrit, and moderate anisocytosis, poikilocytosis and polychromasia- and moderate increase in absolute and relative polymorphonuclear leukocytes. A slight increase in polymorphonuclear leukocytes and enlarged spleens with splenic congestion were also seen in the low-dose group. This chemical was also a strong skin and eye irritant and a weak to potent skin sensitizer in 9 of 10 animals tested. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
10 Sep 1992 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A02/MF A02 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
018800700 |
Origin |
NTIS |
Type |
CAT |