Main Title |
Toxicokinetics of Fenvalerate in Rainbow Trout ('Salmo gairdneri') (Journal Version). |
Author |
Bradbury, S. P. ;
Coats, J. R. ;
McKim, J. M. ;
|
CORP Author |
Environmental Research Lab.-Duluth, MN. ;Iowa State Univ., Ames. Dept. of Entomology. |
Publisher |
c1986 |
Year Published |
1986 |
Report Number |
EPA/600/J-86/485; |
Stock Number |
PB89-104418 |
Additional Subjects |
Toxic substances ;
Insecticides ;
Salmo gairdneri ;
Trout ;
Toxicity ;
Gills ;
Pharmacokinetics ;
Tissue distribution ;
Metabolism ;
Biotransformation ;
Excretion ;
Degration ;
Toxicology ;
Chlorine organic compounds ;
Aquatic organisms ;
Reprints ;
Fenvalerate ;
Benzene acetic acid/cyano(phenoxyphenyl)methyl-chloro-(methylethyl)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-104418 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
An in vivo rainbow trout (Salmo gairdneri) preparation was used to evaluate the gill uptake and toxicokinetics of (3H)fenvalerate ((R,S)-alpha-cyano-3-phenoxybenzyl (R,S)-2-(4-chlorophenyl)-3-methylbutyrate), a synthetic pyrethroid insecticide. Fish were exposed to technical-grade fenvalerate (0.28 or 23 ng/L) or an emulsifiable-concentrate formulation (16 ng/L) for 36 to 48 h. No significant effects of emulsifiers or fenvalerate concentration on uptake were observed. The overall mean gill uptake efficiency was determined to be 28.6. Following 8- to 48-h depuration periods, carcass and bile contained 80 to 90 percent and 10 to 20 percent of the gill-absorbed doses, respectively. Analysis of biliary metabolites indicated that the glucuronide of 4'-HO-fenvalerate was the only significant degradation product. Results from the present study suggest that efficient gill uptake does not explain the extreme sensitivity of fish to fenvalerate. Rather, a low rate of biotransformation and excretion may play a significant role in the susceptibility of rainbow trout to the synthetic pyrethroid insecticides. (Copyright (c) 1986 SETAC.) |
Supplementary Notes |
Pub. in Environmental Toxicology and Chemistry, v5 p567-576 Nov 86. Prepared in cooperation with Iowa State Univ., Ames. Dept. of Entomology. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Toxicokinetics of Fenvalerate in Rainbow Trout ('Salmo gairdneri') (Journal Version). |
Category Codes |
57Y; 57P; 57H; 68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
833026816 |
Origin |
NTIS |
Type |
CAT |