Main Title |
Carcinogenic Potential of Arsenic Compounds in Drinking Water. |
Author |
Shirachi, D. Y. ;
Tu, S. H. ;
McGowan, J. P. ;
|
CORP Author |
University of the Pacific, Stockton, CA.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1986 |
Report Number |
EPA-R-807235; EPA/600/1-86/003; |
Stock Number |
PB86-200854 |
Additional Subjects |
Arsenic ;
Carcinogens ;
Rats ;
Water pollution ;
Concentration(Composition) ;
Liver ;
Dosage ;
Arsenates ;
Drinking water
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-200854 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
56p |
Abstract |
The primary objective of the research project was to determine whether arsenite (AsIII), arsenate (AsV), dimethylarsinic (DMA) and monomethylarsonic acid (MA) were initiator carcinogens and/or promoters of DENA-initiated tumors in the rat liver. The maximum tolerated doses (MTD) of the arsenics to be used in this study were determined by treating male Wistar rats in the drinking water increasing concentrations ranging from 10ppm-2560ppm for 7 weeks, depending upon the arsenic studied. To determine whether the arsenic compounds had an initiator or promoter activity, male Wistar rats were partially hepatectomized, treated with a single dose of diethylnitrosamine and on day 7 started treatment with the MTD of each arsenic for 7, 25 and 43 weeks in the drinking water. |
Supplementary Notes |
Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Project summary rept.. |
PUB Date Free Form |
May 86 |
Category Codes |
6C; 6F; 6T; 68D; 57Z; 57H; 57Y |
NTIS Prices |
PC A04/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
619921842 |
Origin |
NTIS |
Type |
CAT |