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RECORD NUMBER: 30 OF 1173

OLS Field Name OLS Field Data
Main Title Acute and Subchronic Toxicity of 2,4-Dichlorophenol in DC-1 Mice.
Author Borzelleca, J. F. ; Hayes, J. R. ; Condie, L. W. ; Egle, J. L. ;
CORP Author Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-808861; EPA/600/J-85/406;
Stock Number PB86-202512
Additional Subjects Toxicology ; Bioassay ; Mice ; Exposure ; Dosage ; Reprints ; Phenol/dichloro
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB86-202512 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract Male and female CD-1 mice were exposed to 2,4-dichlorophenol (DCP) in drinking water containing 10% emulphor for 90 days at concentrations of 0.2, 0.6, and 2.0 mg/ml. The mean daily consumption values ranged from 46.3 to 542 mg/kg/day for females and 34.9 and 419 mg/kg/day in males. In both sexes, water consumption was lower in the emulphor control group than in the water controls. Female mice tended to consume more of the solutions containing DCP than the vehicle control. There were no significant difference in body weight gain between females in the vehicle control and experimental groups. In males the rate of increase was lower in 2 of 14 weeks at the mid-dose and 4 of 14 weeks at the high dose. No differences were found in terminal organ weights or organ weight ratios in either sex. The only hematological differences were an increase in leukocytes at the high dose and an increase in polymorphonuclears at the low dose in males. Clinical chemistry parameters were altered in females only and include a decrease in creatinine (low dose), an increase in BUN/creatinine ratio (mid dose) and an increase in ALP (high dose).
Supplementary Notes Pub. in Fundamental and Applied Toxicology, v5 n3 p478-486 Jun 85. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Acute and Subchronic Toxicity of 2,4-Dichlorophenol in DC-1 Mice.
PUB Date Free Form c1985
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 621323389
Origin NTIS
Type CAT