||1,2-Dibromoethane Causes Rat Hepatic DNA Damage at Low Doses.
Kitchin, K. T. ;
Brown, J. L. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Liver diseases ;
Alpha amino carboxylic acids ;
Halogenated hydrocarbons ;
SGPT(Serum Alanine Transaminase)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Two oral administrations of 1,2-dibromoethane to adult female rats at doses above 10 micromoles/kg (1.9 mg/kg) caused DNA damage as determined by the alkaline elution technique. Far greater doses (300 micromoles/kg, 56.4 mg/kg) of 1,2-dibromoethane were required to cause other hepatic biochemical effects, such as increased activity of ornithine decarboxylase. In the dose range of 10-300 micromoles/kg, no increase in the activity of serum enzyme alanine transaminase (SGPT) was observed. Of the six organs studied, liver showed the largest amount of DNA damage. Thus, the carcinogen 1,2-dibromoethane caused substantial DNA damage at doses far below those required to show other biochemical effects or frank liver toxicity.
||Pub. in Biochemical and Biophysical Research Communications, v141 n2 p723-727A, 15 Dec 86.
|NTIS Title Notes
||Reprint: 1,2-Dibromoethane Causes Rat Hepatic DNA Damage at Low Doses.
|PUB Date Free Form
||68G; 57F; 57O; 57Y
||PC A02/MF A01