Main Title |
Studies on the Percutaneous Absorption of Parathion and Paraoxon. V. Rate of Absorption of Paraoxon. |
Author |
Fredriksson., Torsten ;
|
CORP Author |
Communicable Disease Center, Atlanta, Ga. |
Year Published |
1961 |
Stock Number |
PB-280 010 |
Additional Subjects |
Pesticides ;
Insecticides ;
Toxicology ;
Enzymes ;
Cholinesterase inhibitors ;
Dosage ;
Responses ;
Parenteral infusions ;
Absorption(Biology) ;
Skin(Anatomy) ;
Cats ;
Bioassay ;
Laboratory animals ;
Reprints ;
Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-280 010 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
4p |
Abstract |
The rate of percutaneous absorption of paraoxon (E 600, or diethyl 4-nitrophenyl phosphate) has been determined by dose-response comparison following this mode of administration and intravenous infusion in the cat. The rate of inhibition of plasma cholinesterase activity was chosen as the parameter. Under the conditions of the study, the rate of percutaneous absorption was found to be constant in a given skin. By extrapolation from the activity curves, it was possible to determine the time required for paraoxon to diffuse from the topical deposit to the blood stream. This latency period was found to be approximately 12 minutes. |
Supplementary Notes |
Pub. in Jnl. of Investigative Dermatology, v38 n4 p233-236, Apr 62. |
Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 11, PB-280 001. |
Title Annotations |
Reprint: Studies on the Percutaneous Absorption of Parathion and Paraoxon. V. Rate of Absorption of Paraoxon, |
PUB Date Free Form |
27 Apr 61 |
Category Codes |
6T; 57Y; 68G; 68E |
NTIS Prices |
(Order as PB-280 001, MF A01) |
Primary Description |
500/01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323739424 |
Origin |
NTIS |
Type |
CAT |