Main Title |
Prenatal Dexamethasone Administration Disrupts the Pattern of Cellular Development in Rat Lung. |
Author |
Navarro, H. A. ;
Kudlacz, E. M. ;
Eylers, J. P. ;
Slotkin, T. A. ;
|
CORP Author |
Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA-R-813769; EPA/600/J-89/377; |
Stock Number |
PB90-216227 |
Additional Subjects |
Lung ;
Toxicology ;
Graphs(Charts) ;
Deoxyribonucleic acids ;
Rats ;
Proteins ;
Gestation ;
Cell division ;
Reprints ;
Dexamethasone ;
Prenatal exposure delayed effects ;
Organ weight ;
Ornithine decarboxylase ;
Beta adrenergic receptors ;
Cell differentiation ;
Isoproterenol
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-216227 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
To examine whether prenatal exposure to glucocorticoids could adversely affect subsequent cellular development of the lung, the authors administered 0.2 mg/kg of dexamethasone to pregnant rats on gestational days 17, 18, and 19. Lungs of the offspring were then examined for patterns of cell acquisition (DNA) and growth (protein). DNA concentration (a marker of cell packing density) and DNA content (a measure of total cell numbers) were reduced during gestation, and the shortfalls in concentration persisted past weaning. Disruption of development was also apparent in the protein/DNA ratio, which was consistently elevated, a finding consistent with cellular hypertrophy. In addition, lung ornithine decarboxylase became coupled to beta-adrenergic receptors prematurely in the dexamethasone group, suggesting that neural control of tissue differentiation is altered. These data indicate that prenatal glucocorticoids may compromise lung development through effects on cell replication and differentiation, which derive, in part, from alterations in the reception of trophic neural signals. (Copyright (c) 1989 Alan R. Liss, Inc.) |
Supplementary Notes |
Pub. in Teratology, v40 p433-438 Nov 89. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Prenatal Dexamethasone Administration Disrupts the Pattern of Cellular Development in Rat Lung. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
018016175 |
Origin |
NTIS |
Type |
CAT |